HOME >> BIOLOGY >> NEWS
Carnegie Mellon University scientists identify genes activated during learning and memory

PITTSBURGHResearchers have long recognized that for learning and memory to take place, certain genes must be activated to alter neuron activity inside the brain. Disruptions in normal gene expression within these neurons can lead to alarming consequences, such as seizures and epilepsy. But identifying and cataloging all the genes involved in learning is a daunting task. In the March 13 issue of BMC Neuroscience, Carnegie Mellon University scientists show how an innovative computational approach can provide a rapid way to identify the likely members of this long sought-after set of genes.

"The work could ultimately lead to the development of drugs to treat neurological disorders," said Alison Barth, assistant professor of biological sciences and a member of the Center for the Neural Basis of Cognition (CNBC). "We also expect this work to provide a valuable platform for any investigator to understand how neurons change at the molecular level during learning and the formation of memory."

As an animal learns and remembers, specific neurons inside its brain are activated. The molecular changes associated with learning alter a neuron's function a process called plasticity. For many years, neuroscientists have known that two factors, CREB and zif268, activate genes involved in neuronal plasticity and learning. CREB and zif268 are transcription factors, binding to a cluster of chemical bases represented in the genetic code as letters. Once bound, they regulate genes that, in turn, dictate the assembly of other proteins that alter a neuron during memory and learning.

The Carnegie Mellon team created a step-by-step set of instructions for a computer to search the letters of code that make up the human genome to find just those genes activated by CREB and zif268. They specifically searched almost 20,000 genes to find those that CREB and zif268 bind to. This work, conducted by Carnegie Mellon undergraduate Andreas Pfenning and supervised by A
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
18-Apr-2007


Page: 1 2

Related biology news :

1. Carnegie Mellons Peter Adams receives EPA research grant
2. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
3. Carnegie Mellons David Sholl identifies new materials
4. Carnegie Mellon University research shows how sensory-deprived brain compensates
5. Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
6. Carnegie Mellon researcher proposes development of artificial cells to fight disease
7. Carnegie Mellon engineers devise new process to improve energy efficiency of ethanol production
8. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
9. Carnegie Mellons Granger Morgan pens op-ed
10. Carnegie Mellon scientist plays key role in unveiling sea urchin genome
11. Carnegie Mellon study reveals that odor discrimination is linked to the timing at which neurons fire

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/4/2019)... JOSE, Calif. (PRWEB) , ... June 04, 2019 ... ... analytical technologies, today announced the appointment of Susan Murphy as the new President ... Coulter Life Sciences?owned by Molecular Devices’ parent company, Danaher Corporation. , Since joining ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University of Vermont ... in BioFactura’s $6M Series B Financing Round. , “With the commitment from ... bring significant financial and business resources to bear as we advance our biopharmaceutical ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 29, 2019 , ... ... interest to our methodology, processes, and diagnostic techniques. The patent applications titled ... IP rights including our proprietary sleep scoring methodology. The approval and success ...
(Date:5/21/2019)... Ethiopia (PRWEB) , ... May 21, 2019 , ... ... Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated ... and malting industry in Africa. The event, which is supported through a partnership ...
(Date:5/8/2019)... ... 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side for a ... and barrel racing, among other activities. When loping around a corner in late 2017, ... a busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought ...
(Date:5/2/2019)... RAPID CITY, S.D. (PRWEB) , ... April 30, 2019 , ... ... of society, from industrial scale macro breweries to local craft breweries, and even home ... scale, involves very complex chemical and biological processes, that when mastered can produce a ...
Breaking Biology Technology:
Cached News: