HOME >> BIOLOGY >> NEWS
Carnegie Mellon scientist plays key role in unveiling sea urchin genome

t in their last common ancestor and, conversely, what genes have appeared more recently in the two lineages since they diverged many hundreds of million years ago.

"Having the sea urchin genome is almost an epiphany. I can see the genes, and it's very exciting," added Ettensohn, who has been studying the sea urchin as a model of development for more than 25 years. Specifically, he focuses on the vast network of proteins needed for these animals to form skeletons through biomineralization.

"If we understand how sea urchins build their skeletons, we can learn more about how we build our skeletons," Ettensohn said. "Additionally, understanding how natural systems build skeletons can help us mimic that in the design of materials to treat bone disease and injury in humans."

As part of the Sea Urchin Genome Sequencing Consortium, Ettensohn contributed 51,000 cDNAs -- about one-third of the total genomic material critical for the assembly of the genome and for the accurate prediction of where genes lie within the DNA sequence.

The Ettensohn lab was also one of 15 labs to annotate sets of genes that comprise the sea urchin genome. Initially, computers assembled the genome sequence and predicted the sea urchin genes. These predictions were then verified by scientists in the lab. Ettensohn annotated the genes involved in biomineralization, the process by which sea urchins form their embryonic skeletons. His work resulted in a comprehensive catalog of all the genes that are actually being used by the embryonic cells responsible for building the skeleton, including when and where the genes are expressed in the embryo.

In the sea urchin embryo, specialized cells produce proteins that mix with mineral crystals, thereby regulating the growth and shape of the emerging skeleton, just as in humans. But having the sea urchin genome has revealed a provocative discovery: many of the biomineralization proteins, especially those that control
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
9-Nov-2006


Page: 1 2 3

Related biology news :

1. Carnegie Mellons Peter Adams receives EPA research grant
2. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
3. Carnegie Mellons David Sholl identifies new materials
4. Carnegie Mellon University scientists identify genes activated during learning and memory
5. Carnegie Mellon University research shows how sensory-deprived brain compensates
6. Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
7. Carnegie Mellon researcher proposes development of artificial cells to fight disease
8. Carnegie Mellon engineers devise new process to improve energy efficiency of ethanol production
9. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
10. Carnegie Mellons Granger Morgan pens op-ed
11. Carnegie Mellon study reveals that odor discrimination is linked to the timing at which neurons fire

Post Your Comments:
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group issues ... (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one of ... on their experience with the Wocket in multiple scenarios and ... Whole Foods and other retailers, making both debit and credit ... also says, "If the company meets their plans in ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Geometry - Global Strategic Business Report" report to their ... Hand Geometry in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts ...
(Date:3/17/2015)... , March 17, 2015 ... company specializing in clinical study management systems, is ... in attendance at ARENA,s Outsourcing in Clinical Trials ... This event provides an excellent forum for MedNet ... flexible and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
(Date:3/27/2015)... , March 27, 2015  Neogen Corporation (NASDAQ: ... adopted a prearranged trading plan in accordance with Securities ... Chairman and CEO of Neogen Corporation, is a minority ... Corporation common stock. Herbert does not have ... appropriate. The filing is only for a portion of ...
(Date:3/27/2015)... 2015  Peter Walter was chosen as winner of ... work on how proteins are transported between cellular compartments ... that cells use to handle stress tied to the ... of biochemistry at the University of California, San Francisco. ... of human diseases related to defective protein folding and ...
(Date:3/27/2015)... , March 27, 2015 WuXi PharmaTech ... open-access R&D capability and technology platform company serving ... announced today that an Investigational New Drug (IND) ... for rheumatoid arthritis has been accepted for review ... In September 2012, MedImmune, the ...
(Date:3/27/2015)... New York (PRWEB) March 27, 2015 ... the 2015 application period for 43North - the world’s ... prizes, including a grand prize of $1 million, six ... entrepreneurs from around the world to compete for prizes ... funded enterprises in the Western New York region. ...
Breaking Biology Technology:Neogen CEO adopts 10b5-1 Trading Plan 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5
Cached News: