HOME >> BIOLOGY >> NEWS
Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

PITTSBURGH -- Carnegie Mellon University scientists have made an important discovery that aids the understanding of why HIV enters immune cells with ease. The researchers found that after HIV docks onto a host cell, it dramatically lowers the energy required for a cell membrane to bend, making it easier for the virus to infect immune cells. The finding, in press in Biophysical Journal, will provide vital data to conduct future computer simulations of HIV dynamics to help further drug discovery and prevent deadly infections.

We found that HIV fusion peptide dramatically decreases the amount of energy needed to bend a cell-like membrane, said Stephanie Tristram-Nagle, associate research professor of biological physics at Carnegie Mellon. This helps membranes to curve, a necessary step for HIV to fuse with an immune cell as it infects it.

The Carnegie Mellon scientists used X-rays to study how HIV fusion peptide (part of a larger protein) affected the energy of manufactured lipid bilayers made to mimic normal cell membranes. Lipid bilayers provide a protective barrier for the cell against intruders, yet also contain molecules to recognize and communicate with other cells or get nutrients. Cells also communicate with one another via small, membrane-bound vesicles that contain proteins or other molecular cargo. When delivering their goods, vesicles from one cell fuse with the outermost membrane of another cell to form a series of hybrid structures called fusion intermediates.

Through evolution, viruses have also become skilled at fusing with cells to unload their genetic contents, which turn host cells into virus-producing factories. In the case of HIV, a molecule called gp120 initially helps the virus lock onto its host T cell, a cell critical for maintaining immunity. Another protein gp41 then enables HIV to penetrate a T-cell membrane. Fusion takes place specifically through a short stretch of gp41 called fusion peptide 23, or FP-23 for short
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
25-Jul-2007


Page: 1 2 3

Related biology news :

1. Carnegie Mellons Peter Adams receives EPA research grant
2. Carnegie Mellons David Sholl identifies new materials
3. Carnegie Mellon University scientists identify genes activated during learning and memory
4. Carnegie Mellon University research shows how sensory-deprived brain compensates
5. Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
6. Carnegie Mellon researcher proposes development of artificial cells to fight disease
7. Carnegie Mellon engineers devise new process to improve energy efficiency of ethanol production
8. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
9. Carnegie Mellons Granger Morgan pens op-ed
10. Carnegie Mellon scientist plays key role in unveiling sea urchin genome
11. Carnegie Mellon study reveals that odor discrimination is linked to the timing at which neurons fire

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
(Date:3/22/2017)... , March 21, 2017 Vigilant ... company serving law enforcement agencies, announced today the appointment ... as director of public safety business development. ... law enforcement experience, including a focus on the aviation ... his most recent position, Mr. Sheridan served as the ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... , March 24, 2017   Sienna Biopharmaceuticals, Inc. ... company, today announced that Richard Peterson will ... 24.   Peterson, who brings more than two ... Smither , who is retiring at the end of ... advisory capacity. Peterson joins Sienna from Novan, Inc., where ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... exhibits both viscous and elastic characteristics when deformed, which is identical to how ... to gently absorb compressive forces and return to its natural state along a ...
(Date:3/23/2017)... , Mar 23, 2017 Research ... Products: Global Markets" report to their offering. ... The Global ... $466.6 Billion in 2016 at a CAGR of 8.9%, ... energetic and non-energetic bioproducts into seven major product segments: bio-derived ...
(Date:3/23/2017)... Mass. , March 23, 2017 /PRNewswire/ ... partner to global in vitro diagnostics manufacturers ... of the industry,s first multiplexed Inherited ... disease testing by next-generation sequencing (NGS). The ... were developed with input from industry experts ...
Breaking Biology Technology:
Cached News: