HOME >> BIOLOGY >> NEWS
Carnegie Mellon study identifies impact of neural connections in learning process

studies using viral over-expression systems supports the notion that production of certain AMPA receptors is increased and that they are transported to the synapse during learning. Neuroscientists have always thought implicitly that this phenomenon underlies learning and memory," said Barth. "Our study reveals for the first time in vivo the dynamic activity of these receptors within a single synapse and that these changes result in experience-dependent plasticity during a specific behavioral experience."

Barth's strategy to reveal plasticity in a single synapse involved a two-step approach. First, she used a novel tool she created--a transgenic mouse that couples the green fluorescent protein (GFP) with the gene c-fos, which turns on when nerve cells are activated. Using this method, Barth was able to "light up" clusters of neurons in living brain tissue that were activated during a specific rearing condition --experiencing the world through one whisker. By locating such a cluster of glowing neurons, she could precisely identify the area of the brain involved in processing sensory input from that single whisker. Once these neurons were located, Barth examined how the inputs to these neurons had been modified by experience.

Barth and graduate student Roger Clem, the lead author on the study, found that this change in sensory experience causes a subtle, but very significant, change in AMPA receptor properties at a defined group of synapses in an area of the brain identified by fos-GFP labeling. Barth and Clem achieved this finding by using an electrophysiological technique called patch clamping to detect unique voltage "signatures" that characterize and differentiate in real-time AMPA receptors.

Why would detecting different AMPA receptors be important? Different subtypes of AMPA receptors are highly regulated within a cell. Each AMPA receptor is made from varying combinations of four subunits: GluR1, GluR2, GluR3 or GluR4. The different ratio
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
1-Mar-2006


Page: 1 2 3

Related biology news :

1. Carnegie Mellons Peter Adams receives EPA research grant
2. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
3. Carnegie Mellons David Sholl identifies new materials
4. Carnegie Mellon University scientists identify genes activated during learning and memory
5. Carnegie Mellon University research shows how sensory-deprived brain compensates
6. Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
7. Carnegie Mellon researcher proposes development of artificial cells to fight disease
8. Carnegie Mellon engineers devise new process to improve energy efficiency of ethanol production
9. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
10. Carnegie Mellons Granger Morgan pens op-ed
11. Carnegie Mellon scientist plays key role in unveiling sea urchin genome

Post Your Comments:
(Date:7/28/2014)... RENO Norwegian explorer Roald Amundsen became the first ... 1911. More than 100 years later, an international team ... Research Institute (DRI) have proven that air pollution from ... 16 ice cores collected from widely spaced locations around ... created the most accurate and precise reconstruction to date ...
(Date:7/27/2014)... nicotine and cotinine, a metabolite of nicotine, can potentially ... smoke. , The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or NNK is produced ... up in the tobacco smoke. Once inhaled, it is ... activated by a variety of enzymes called Cytochrome P450 ... can partially interfere with the activation of NNK, and ...
(Date:7/27/2014)... wiped them out if it had taken place slightly ... fresh study using up-to-date fossil records and improved analytical ... of the prehistoric creatures, demise, some 66 million years ... years before a 10km-wide asteroid struck what is now ... volcanic activity, changing sea levels and varying temperatures. ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2Dinosaurs fell victim to perfect storm of events, study shows 2
(Date:7/28/2014)... The National Model Aviation Museum, located ... pleased to announce that it has been granted full ... United States Air Force. , The certification is the ... this spring with an on-site inspection by Sarah Sessions, ... The National Museum of the United States Air ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market Outlook ... Canada Endoscopy Visualization Systems market. The report provides ... units) and average prices (in US dollars) within ... Endoscopy Visualization Systems and Low-End Endoscopy Visualization Systems. ... , The report also provides company shares and ...
(Date:7/25/2014)... NY (PRWEB) July 26, 2014 ... Review, H2, 2014" provides data on the Ischemic ... report provides elemental information and data relating to ... Stroke. , View full global Ischemic Stroke Research ... includes an overview of the trial numbers and ...
(Date:7/25/2014)... 25, 2014 Amgen (NASDAQ: AMGN ... a $0.61 per share dividend for the third quarter ... 5, 2014, to all stockholders of record as of ... About Amgen Amgen is committed to unlocking ... illnesses by discovering, developing, manufacturing and delivering innovative human ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3
Cached News: