HOME >> BIOLOGY >> NEWS
Carnegie Mellon study identifies impact of neural connections in learning process

studies using viral over-expression systems supports the notion that production of certain AMPA receptors is increased and that they are transported to the synapse during learning. Neuroscientists have always thought implicitly that this phenomenon underlies learning and memory," said Barth. "Our study reveals for the first time in vivo the dynamic activity of these receptors within a single synapse and that these changes result in experience-dependent plasticity during a specific behavioral experience."

Barth's strategy to reveal plasticity in a single synapse involved a two-step approach. First, she used a novel tool she created--a transgenic mouse that couples the green fluorescent protein (GFP) with the gene c-fos, which turns on when nerve cells are activated. Using this method, Barth was able to "light up" clusters of neurons in living brain tissue that were activated during a specific rearing condition --experiencing the world through one whisker. By locating such a cluster of glowing neurons, she could precisely identify the area of the brain involved in processing sensory input from that single whisker. Once these neurons were located, Barth examined how the inputs to these neurons had been modified by experience.

Barth and graduate student Roger Clem, the lead author on the study, found that this change in sensory experience causes a subtle, but very significant, change in AMPA receptor properties at a defined group of synapses in an area of the brain identified by fos-GFP labeling. Barth and Clem achieved this finding by using an electrophysiological technique called patch clamping to detect unique voltage "signatures" that characterize and differentiate in real-time AMPA receptors.

Why would detecting different AMPA receptors be important? Different subtypes of AMPA receptors are highly regulated within a cell. Each AMPA receptor is made from varying combinations of four subunits: GluR1, GluR2, GluR3 or GluR4. The different ratio
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
1-Mar-2006


Page: 1 2 3

Related biology news :

1. Carnegie Mellons Peter Adams receives EPA research grant
2. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
3. Carnegie Mellons David Sholl identifies new materials
4. Carnegie Mellon University scientists identify genes activated during learning and memory
5. Carnegie Mellon University research shows how sensory-deprived brain compensates
6. Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
7. Carnegie Mellon researcher proposes development of artificial cells to fight disease
8. Carnegie Mellon engineers devise new process to improve energy efficiency of ethanol production
9. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
10. Carnegie Mellons Granger Morgan pens op-ed
11. Carnegie Mellon scientist plays key role in unveiling sea urchin genome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 22, 2017 , ... AESKU.GROUP, an innovation leader in ... Technologien GmbH, thereby expanding its product portfolio to include allergy and food intolerance ... atopic eczema or a food allergy. Allergies are escalating to epidemic proportions and ...
(Date:6/22/2017)... ... June 22, 2017 , ... For the months of ... a Spotlight series on “Cell Therapy Regulation” for its regenerative medicine ... on the unique regulatory challenges of stem cell medical research. , Stem cell ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... The first ... took 20 years until the first data on cross-contamination of human cell lines with ... been an increasing issue in cell culture labs and is associated with dramatic consequences ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to ... was determined to be appropriate as a screening test at dairies and farms for ... EZ system, and the Charm EZ Lite system. These systems are a combination incubator ...
Breaking Biology Technology:
Cached News: