HOME >> BIOLOGY >> NEWS
Case Western Reserve University chemist takes on HIV-1 virus with $1M support from NIH

een known for years that the subunits can come apart, mostly everyone has ignored this fact in research, said Barkley.

She sees the potential of interfering with how the subunits come together as one way of thwarting the spread of the virus.

"We know that the subunits have to be together to catalyze DNA synthesis, and that the second generation RT inhibitors can alter how tightly the two subunits stick together," Barkley explains. "We think the way that the subunits come together play a role in the protein's -- and thus the patient's -- resistance to drugs and in how the drugs inhibit the DNA synthesis."

"No one has looked at how these pieces come together and how it is related to the catalysis other than they knew it had to happen for the virus to grow. This is where we started working," she said.

Barkley began work on the HIV-1's reverse transcriptase enzyme in 1998 through collaboration with Stuart Le Grice, the former director of the Center for AIDS Research at the Case School of Medicine.

She said researchers have crystallized the RT and then looked its 3-dimensional structure using x-ray diffraction, but according to Barkley, the structure does not tell how it works.

She will collaborate with Patrick Wintrode in the Case School of Medicine's department of physiology and biophysics, who uses a new technique that tracks the fast exchanges of protons for deuterons on the protein's surface. This technique will provide another view of how the protein functions and as well as answers to what happens when the two subunits are apart and then come together.

"It has been difficult," said Barkley. "Everything we have done with this protein is that you try it and think it is going to be a straightforward method that is used on many other proteins and will work on this one, but it doesn't work as expected."

This new approach may be the answer to understanding the protein, she said.'"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
18-Aug-2006


Page: 1 2 3

Related biology news :

1. Study finds Western-style meat-sweet diet increases risk of breast cancer in postmenopausal women
2. Case Western Reserve University School of Medicine researchers awarded $27M for TB research
3. Case Western researcher, international team call for better global warming forecasting
4. WHSRN awarded major grant to foster shorebird conservation throughout the Western Hemisphere
5. Case Western Reserve University biologists suspect lightning fires help preserve oak forests
6. Case Western Reserve University licenses methoxyamine to Tracon
7. Case Western Reserve University paleontologist discovers South American mammal fossils
8. Case Western Reserve University researchers find protein associated with brain cell death
9. In Western bluebird as well as human families, accumulated wealth encourages stability
10. Case Western Reserve University School of Medicine gets $4 million to make smart nanoparticles
11. ASU students host first annual Western Regional Bioethics Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: