HOME >> BIOLOGY >> NEWS
Cell enzyme may help suppress cancer development

COLUMBUS, Ohio A new study shows that an enzyme that normally alters the activity of other protein molecules in cells may also help prevent cancer.

The enzyme is known as PTPRO (for "protein tyrosine phosphatase receptor-type O"). When the gene responsible for producing PTPRO is silenced, as can happen in lung cancer, for example, the amount of the enzyme drops, allowing the cells to grow when they shouldn't.

The research, led by investigators at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, may offer a new target for cancer therapy and may lead to new ways to diagnose some cancers and determine a patient's prognosis and response to treatment.

The findings were published in a recent issue of the Proceedings of the National Academy of Sciences.

"This appears to be the first report of an enzyme also serving as a tumor suppressor," says study leader Samson T. Jacob, William C. and Joan E. Davis Professor in cancer research and professor of molecular and cellular biochemistry and internal medicine. "It shouldn't come as a surprise, however, because of the nature of this enzyme."

PTPRO removes phosphate groups from the amino-acid tyrosine found in specific proteins. Some proteins become activated and some become inactivated when phosphate groups are removed. It is likely that the silencing of PTPRO alters the phosphate levels of some of these proteins and helps initiate processes that lead to cancer.

In this study, Jacob and his colleagues show that the PTPRO gene is silenced gradually by a process known as methylation. Methylation causes the addition of small chemical units known as methyl groups to a gene. As methyl units accumulate on a gene, the gene become less active and fewer copies of its protein are made.

In this case, silencing of the PTPRO gene causes a drop in the level of the PTPRO enzyme. That,
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
4-Nov-2004


Page: 1 2

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
3. NIEHS researchers identify enzyme critical in DNA replication
4. Scientists discover role of enzyme in DNA repair
5. Researchers create model of cancer-preventing enzyme, study how it works
6. Viral enzyme recruited in fight against ear infection
7. RNA enzyme structure offers a glimpse into the origins of life
8. Researchers create artificial enzyme that mimics the bodys internal engine
9. Scientists identify specific enzymes that make meningitis hard to fight
10. Fetal heart-cell enzyme important in onset of heart failure
11. Sentry enzyme blocks two paths to Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/18/2017)... Calif. , April 18, 2017  Socionext Inc., a global ... of a media edge server, the M820, which features the company,s ... recognition software provided by Tera Probe, Inc., will be showcased during ... at the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
Breaking Biology Technology:
Cached News: