HOME >> BIOLOGY >> NEWS
Cell enzyme may help suppress cancer development

COLUMBUS, Ohio A new study shows that an enzyme that normally alters the activity of other protein molecules in cells may also help prevent cancer.

The enzyme is known as PTPRO (for "protein tyrosine phosphatase receptor-type O"). When the gene responsible for producing PTPRO is silenced, as can happen in lung cancer, for example, the amount of the enzyme drops, allowing the cells to grow when they shouldn't.

The research, led by investigators at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, may offer a new target for cancer therapy and may lead to new ways to diagnose some cancers and determine a patient's prognosis and response to treatment.

The findings were published in a recent issue of the Proceedings of the National Academy of Sciences.

"This appears to be the first report of an enzyme also serving as a tumor suppressor," says study leader Samson T. Jacob, William C. and Joan E. Davis Professor in cancer research and professor of molecular and cellular biochemistry and internal medicine. "It shouldn't come as a surprise, however, because of the nature of this enzyme."

PTPRO removes phosphate groups from the amino-acid tyrosine found in specific proteins. Some proteins become activated and some become inactivated when phosphate groups are removed. It is likely that the silencing of PTPRO alters the phosphate levels of some of these proteins and helps initiate processes that lead to cancer.

In this study, Jacob and his colleagues show that the PTPRO gene is silenced gradually by a process known as methylation. Methylation causes the addition of small chemical units known as methyl groups to a gene. As methyl units accumulate on a gene, the gene become less active and fewer copies of its protein are made.

In this case, silencing of the PTPRO gene causes a drop in the level of the PTPRO enzyme. That,
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
4-Nov-2004


Page: 1 2

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
3. NIEHS researchers identify enzyme critical in DNA replication
4. Scientists discover role of enzyme in DNA repair
5. Researchers create model of cancer-preventing enzyme, study how it works
6. Viral enzyme recruited in fight against ear infection
7. RNA enzyme structure offers a glimpse into the origins of life
8. Researchers create artificial enzyme that mimics the bodys internal engine
9. Scientists identify specific enzymes that make meningitis hard to fight
10. Fetal heart-cell enzyme important in onset of heart failure
11. Sentry enzyme blocks two paths to Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... ... systems for controlled-environment cultivation applications. VYPR 2 is well suited for sole-source and ... and ornamental growing markets. , “As an all-purpose light which can be ...
(Date:11/13/2018)... ... November 12, 2018 , ... ... events and webinars, will be hosting its 9th Annual Clinical Diagnostics & ... and treatments available, and updates in regulatory processes to ensure patient safety and ...
(Date:11/13/2018)... ... 13, 2018 , ... Kenall has enhanced the popular MedMaster MAEC Series LED ... linear overbed luminaires are equipped with symmetric ambient and asymmetric exam modes, and an ... Intended to be specified in pairs, the MAEC is 8” x 48” and has ...
Breaking Biology News(10 mins):
(Date:11/9/2018)... ... November 08, 2018 , ... ... PhD, co-Founder, Chief Executive Officer and President of Andes Biotechnologies, to its Scientific ... world, Dr. Valenzuela brings to uBiome expertise on the genetic studies of hepatitis ...
(Date:11/7/2018)... ... 2018 , ... Diversified Technologies, Inc. (DTI) has installed a PEF ... Algae Technology and Innovation at ASU. Funded by a USDA NIFA SBIR, the purpose ... algal and predator control applications. , Algae ponds get up to 50% consumed by ...
(Date:11/5/2018)... ... November 05, 2018 , ... ... educational support for healthcare professionals through its website, http://www.glycomark.com , as part ... live chat and video option via the website in November from 9 a.m. ...
(Date:10/31/2018)... ... October 30, 2018 , ... Rooam , the premier payment platform for ... winter. After its acquisition of the Tally payment app, the leading payment platform in ... Rooam will grow its market share and increase the number of restaurant and bar ...
Breaking Biology Technology:
Cached News: