HOME >> BIOLOGY >> NEWS
Cell receptor may lead to new 'biomarker' for pancreatic cancer

CINCINNATI -- A research team led by University of Cincinnati (UC) scientists has identified a potential biological target for pancreatic cancer, a finding they say could help scientists better understand -- and eventually treat -- the disease that kills more than 33,000 people each year.

In laboratory studies led by Andrew Lowy, MD, and Susan Waltz, PhD, the Cincinnati researchers found that a specific cell receptor -- known as the RON receptor tyrosine kinase -- was overexpressed, or increased, in pancreatic cancer cells. This, says Waltz, suggests the receptor may also contribute to the diseases development.

The RON receptor has been found to be active in several cancers -- including breast cancer -- but its role in pancreatic cancer was unknown. This is one of the first studies, published in the July 1, 2007, issue of the journal Cancer Research, to report a link between the RON receptor and pancreatic cancer.

Receptor tyrosine kinases are proteins on the cell surface used to activate specific body functions -- for example cell growth and migration.

A normal pancreas has very low levels of RON, but our study showed that as tumors progress, so does the level of RON expression in the pancreas cells -- and those overexpressed levels were maintained in metastases, the areas that the tumors spread to, explains Waltz, associate professor and director of the oncology research program in UCs surgery department.

The team found that the RON receptor was active in 93 percent of what is known as pancreatic intraepithelial neoplasia, an early form of pancreatic duct cancer. In addition, the receptor was present in 79 percent of primary pancreatic cancers and 83 percent of metastatic cancers.

UC researchers believe the RON receptors signaling pathways could be a key factor contributing to pancreatic cancer progression. Waltz says if the receptor could be blocked, it would give drug developers a new target for R
'"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
1-Jul-2007


Page: 1 2

Related biology news :

1. Menthol receptor also important in detecting cold temperatures
2. Systems characterization of cell surface receptors
3. OHSU lab finds meth receptor that could lead to therapy
4. Joslin study indicates insulin receptors play a critical role in promoting islet growth
5. Vitamin D, variations in its receptor and prostate cancer
6. Study advances evidence for receptors role in alcohol pleasure and problems
7. Longevity by a nose (or odorant receptor)
8. The G allele of the mu-opioid receptor gene is linked to craving for alcohol
9. Identification of carbon dioxide receptors in insects may help fight infectious disease
10. Researchers find docking sites for glucocorticoid receptor and Hsp90
11. Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... September 20, 2018 , ... We are ... which supports the recently launched NovoCyte QuanteonTM flow cytometers ... NovoSampler® Pro products. , In addition to the functionalities supporting ...
(Date:9/22/2018)... ... , ... Women who undergo breast implant surgery naturally want ... them against uninsured expenses for unexpected complications. Women can now elect low-cost, extensive ... for greater peace of mind if an issue should arise, and the ...
(Date:9/15/2018)... ... ... The first ever production picosecond-domain laser with a 785?nm wavelength was recently developed ... often the colors most resistant to laser removal. , A clinical trial published in ... Laser Medicine and Surgery, Inc. (ASLMS) investigated the safety and efficacy of the new ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... Wis. (PRWEB) , ... September 06, 2018 , ... ... which runs from September 25th-28th is a meeting of “The industry’s preeminent event ... AptaFluor®, provide drug discovery scientists powerful tools to study these emerging targets in ...
(Date:9/1/2018)... ... 2018 , ... Rudina Thanasi, a scientifically validated holistic energy ... treated nutraceutical supplement used in combating inflammation and autoimmune disorders. , ... as, organ-specific inflammation. The reported data is as follows: , More than ...
(Date:8/29/2018)... ... 28, 2018 , ... Cognition Corporation ®, a software company specializing in ... NAVIGATE2018 . , Ryan Ward, Director of Engineering at Zimmer Biomet, has been ... engineer and manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus ...
(Date:8/29/2018)... ... 28, 2018 , ... USDM Life Sciences , the leading risk management, ... announces that Manu Vohra will deliver a presentation at the BoxWorks 2018 ... Box for GxP in 30 Days” , When: Thursday, August 30, 1:00-1:50 PM PT, ...
Breaking Biology Technology:
Cached News: