HOME >> BIOLOGY >> NEWS
Cellular cues identified for stroke recovery

When a stroke strikes, the supply of blood to the part of the brain affected is interrupted, starving it of oxygen. Brain cells can be seriously damaged or die, impairing local brain function.

But the brain is a battler. Within weeks of a stroke, new blood vessels begin to form, and, like marching ants, newly born neurons migrate long distances to the damaged area to aid the regeneration process. What's not known is what the right cellular environment is, and what the cellular cues are for this process of regeneration and migration to take place.

Now, in the Journal of Neuroscience, currently online, S. Thomas Carmichael, M.D., Ph.D., an assistant professor in the Department of Neurology at the UCLA Geffen School of Medicine, and colleagues report that in the mouse model, this neuron march is the direct result of signaling from the newly blooming blood vessels, thus casually linking angiogenesis the development of new blood vessels and neurogenesis, the birth of new neurons. Further, they have identified what these molecular signals are. The results hold promise for eventual clinical applications that may spur brain repair after stroke.

Stroke is the leading cause of adult disability, said Carmichael. And while much is known about the mechanisms of cell death in stroke, little is known about the mechanisms of neurological recovery after a stroke. His lab studies the mechanisms of brain repair and the recovery of function after a stroke.

Recent research has revealed that in the adult brain, new neurons form in a region of the forebrain known as the subventricular zone (SVZ). In mice, after a stroke was initiated in a part of the brain located far from the SVZ, the researchers, using a combination of mitotic, genetic, and viral labeling, tracked newly formed neuroblasts (immature brain cells from which mature adult neurons form) as they traveled through healthy brain tissue to the stroke area. Once there, these immature neu
'"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
21-Dec-2006


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular pathway yields potential new weapon in vaccine arsenal
4. Cellular killer also important to memory
5. Cellular traffic backups implicated in skeletal malformations
6. Cellular antennae on algae give clues to how human cells receive signals
7. Cellular scale drug delivery from the inside out
8. Cellular dumping site is not garbage after all
9. Cellular power plants also fend off viruses
10. Link identified between Alzheimers disease and glaucoma
11. Gene identified for Crohns disease in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... ... April 30, 2020 , ... Flagship Biosciences , providers ... a biopharmaceutical and regulatory services advisor. The companies now deliver regulatory strategy and ... are taking a collaborative approach to empower more confident and informed regulatory decisions ...
(Date:4/30/2020)... ... April 29, 2020 , ... ... continued growth – delivering innovative solutions for a wide range of industries including ... government agencies. A month into the new decade, it was clear to company ...
(Date:4/22/2020)... ... 20, 2020 , ... RCH Solutions (RCH ), a global provider of ... hiring of Michael Wlodarczyk as Director of Sales and Business Development. Based out of ... company’s already strong presence across the Northeast. , “We continue to see increased demand ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... May 19, 2020 , ... Experienced periodontist in Eden Prairie, MN, ... and bone grafting through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to gently ... prepare a patient for dental implants, especially when the implants need to be placed ...
(Date:5/21/2020)... , ... May 20, 2020 , ... ... of Simon Prakash, who will serve as the company’s executive vice president of ... time when Exo is disrupting the medical imaging space, bringing more than 24 ...
(Date:5/15/2020)... ... May 14, 2020 , ... Children with defective heart valves ... before becoming adults. The reason: there are no heart valve prosthetics designed to ... Department of Defense has awarded Draper, Boston Children’s Hospital and Seattle Children’s Research ...
(Date:5/15/2020)... Mass. (PRWEB) , ... May 15, 2020 , ... Sentien ... the appointment of Richard Ganz as Executive Chairman. Mr. Ganz will continue to ... years, as well as work closely with CEO Brian Miller and Sentien’s management team. ...
Breaking Biology Technology:
Cached News: