HOME >> BIOLOGY >> NEWS
Cellular dumping site is not garbage after all

Cells can reuse the chemical messengers that carry genetic information to the machinery that makes proteins. Sometimes cells shuttle the messengers to storage and later reactivate them to make proteins, according to new research.

Learning how cells regulate the newly discovered "mRNA cycle" may provide insights into how the cellular machinery runs amok in diseases like cancer.

Scientists had previously thought the messenger molecules, known as mRNAs, were manufactured, used, decommissioned and then sent on a one-way journey to the garbage dump.

These cellular garbage dumps, called P-bodies, turn out to be storage depots, not landfills. After use, mRNA molecules are temporarily deactivated for storage purposes. The cell can then either destroy the mRNA or recondition pre-used mRNA so it can be put back into service if needed.

P-bodies are also involved in determining whether specific mRNAs are used to make proteins, a process called translation.

"We were surprised to find that the P-bodies were involved in regulating translation," said research team leader Roy Parker, a Regents' Professor of molecular and cellular biology at The University of Arizona in Tucson and an Investigator with the Howard Hughes Medical Institute. In 2003, his lab was the first to name and describe a function for P-bodies.

Parker said of the new finding, "It suggests P-bodies have a much broader role in controlling the activities of the cell than we realized."

Parker and first author Jeff Coller report P-bodies' role in the control of translation in the Sept. 23 issue of the journal Cell. Coller, who did the research while at UA as a postdoctoral fellow with the Howard Hughes Medical Institute, is now an assistant professor in the Center for RNA Molecular Biology at Case Western Reserve University in Cleveland, Ohio.

The Parker lab's findings about P-bodies serving as storage depots was released online Sept. 1, 2005 and will be pu
'"/>

Contact: Mari N. Jensen
mnjensen@email.arizona.edu
520-626-9635
University of Arizona
22-Sep-2005


Page: 1 2 3

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular pathway yields potential new weapon in vaccine arsenal
4. Cellular cues identified for stroke recovery
5. Cellular killer also important to memory
6. Cellular traffic backups implicated in skeletal malformations
7. Cellular antennae on algae give clues to how human cells receive signals
8. Cellular scale drug delivery from the inside out
9. Cellular power plants also fend off viruses
10. World Wildlife Fund warns against iron dumping experiment near the Galapagos Islands
11. MIT warns of dumping seafood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
(Date:3/22/2017)... 2017   Neurotechnology , a provider of ... announced the release of the SentiVeillance 6.0 ... facial recognition using up to 10 surveillance, security ... The new version uses deep neural-network-based facial detection ... utilizes a Graphing Processing Unit (GPU) for enhanced ...
Breaking Biology News(10 mins):
(Date:5/21/2017)... ... May 19, 2017 , ... Ovation Fertility scientists’ work ... Association of Bioanalysts (AAB) and the College of Reproductive Biology (CRB) today and ... commitment to excellence in clinical laboratory services and regulations. , “We are ...
(Date:5/18/2017)... (PRWEB) , ... May 18, 2017 , ... ... activities. The Tapas Cooking Challenge is a two-hour team-building package designed for ... menu created by Chef Jodi Abel, which include items, such as Blackened Shrimp ...
(Date:5/18/2017)... BARBARA, CALIFORNIA (PRWEB) , ... May 17, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... Chairman of the UDIs and Traceability for Medical Devices conference in Brussels, Belgium. ...
(Date:5/16/2017)... ... May 16, 2017 , ... ... its global Genedata Screener User Group Meetings, which will be held ... opportunity to share best practices in screening data analysis and learn about the ...
Breaking Biology Technology:
Cached News: