HOME >> BIOLOGY >> NEWS
Cellular dumping site is not garbage after all

Cells can reuse the chemical messengers that carry genetic information to the machinery that makes proteins. Sometimes cells shuttle the messengers to storage and later reactivate them to make proteins, according to new research.

Learning how cells regulate the newly discovered "mRNA cycle" may provide insights into how the cellular machinery runs amok in diseases like cancer.

Scientists had previously thought the messenger molecules, known as mRNAs, were manufactured, used, decommissioned and then sent on a one-way journey to the garbage dump.

These cellular garbage dumps, called P-bodies, turn out to be storage depots, not landfills. After use, mRNA molecules are temporarily deactivated for storage purposes. The cell can then either destroy the mRNA or recondition pre-used mRNA so it can be put back into service if needed.

P-bodies are also involved in determining whether specific mRNAs are used to make proteins, a process called translation.

"We were surprised to find that the P-bodies were involved in regulating translation," said research team leader Roy Parker, a Regents' Professor of molecular and cellular biology at The University of Arizona in Tucson and an Investigator with the Howard Hughes Medical Institute. In 2003, his lab was the first to name and describe a function for P-bodies.

Parker said of the new finding, "It suggests P-bodies have a much broader role in controlling the activities of the cell than we realized."

Parker and first author Jeff Coller report P-bodies' role in the control of translation in the Sept. 23 issue of the journal Cell. Coller, who did the research while at UA as a postdoctoral fellow with the Howard Hughes Medical Institute, is now an assistant professor in the Center for RNA Molecular Biology at Case Western Reserve University in Cleveland, Ohio.

The Parker lab's findings about P-bodies serving as storage depots was released online Sept. 1, 2005 and will be pu
'"/>

Contact: Mari N. Jensen
mnjensen@email.arizona.edu
520-626-9635
University of Arizona
22-Sep-2005


Page: 1 2 3

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular pathway yields potential new weapon in vaccine arsenal
4. Cellular cues identified for stroke recovery
5. Cellular killer also important to memory
6. Cellular traffic backups implicated in skeletal malformations
7. Cellular antennae on algae give clues to how human cells receive signals
8. Cellular scale drug delivery from the inside out
9. Cellular power plants also fend off viruses
10. World Wildlife Fund warns against iron dumping experiment near the Galapagos Islands
11. MIT warns of dumping seafood

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cellular dumping site not garbage after all

(Date:8/28/2014)... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the American Society of Human Genetics from October 18 ... awards are meant to promote the entry of students, ... mainstream of the basic science community and to encourage ... of Human Genetics. This year MARC conferred 16 ...
(Date:8/28/2014)... groups and clinicians is critical to the development ... of Georgia research. , A qualitative study of ... that role models for successful breastfeeding help positively ... "Mothers who received that support are more likely ... Alex Anderson, an associate professor in the College ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
Cached News: