HOME >> BIOLOGY >> NEWS
Cellular killer also important to memory

CHAMPAIGN, Ill. -- A protein known primarily for its role in killing cells also plays a part in memory formation, researchers at the University of Illinois at Urbana-Champaign report. Their work exploring how zebra finches learn songs could have implications for treatment of neurodegenerative conditions such as dementia and Alzheimer's disease.

When activated, the enzyme caspase-3 triggers a synaptic process essential for memory storage, according to Graham R. Huesmann and David F. Clayton of the department of cell and developmental biology and of the U. of I. Beckman Institute for Advanced Science and Technology. Their article, which appears in the Dec. 21 issue of the journal Neuron, describes their findings, which provide "the first direct evidence of a change in the availability of activated caspase-3 protein in the brain during the process of memory formation."

Caspase-3 is best known for its role in a biochemical cascade that leads to apoptotic cell death. These new findings demonstrate that the enzyme acts differently under different conditions, and suggest that its regulation in the brain is more complex than previously thought. Huesmann and Clayton examined the brains of zebra finches after exposing the birds to tape recordings of the songs of other birds. They found an increase in the concentration of activated caspase-3 in post-synaptic sites of the auditory forebrain shortly after the birds were exposed to unfamiliar bird songs. Exposure to familiar songs caused no significant increase in the enzyme.

The researchers demonstrated that the activated form of caspase-3 is short-lived and highly localized, which may explain why the enzyme does not trigger apoptosis.

They also showed that activated caspase-3 is always present in brain cells, but that it is usually bound by an inhibitor, BIRC4. For a short time after the birds are exposed to novel songs, the inhibitor releases the activated caspase-3. The concentration of
'"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
21-Dec-2006


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular pathway yields potential new weapon in vaccine arsenal
4. Cellular cues identified for stroke recovery
5. Cellular traffic backups implicated in skeletal malformations
6. Cellular antennae on algae give clues to how human cells receive signals
7. Cellular scale drug delivery from the inside out
8. Cellular dumping site is not garbage after all
9. Cellular power plants also fend off viruses
10. Aphids make chemical weapons to fight off killer ladybirds
11. Revealed -- Mosquito genes that could be controlling the spread of killer viruses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2020)... ... May 29, 2020 , ... ... transformation for enterprises globally, has collaborated with EchoNous Inc. to develop the cloud-based ... can measure systolic heart function, which has been clinically tested versus expert measurements, ...
(Date:5/28/2020)... , ... May 28, 2020 , ... ... that interim results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) ... Meeting which will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, ...
(Date:5/21/2020)... ... May 19, 2020 , ... ... provider of operations management solutions, today introduced BioMed to their award-winning computerized ... platform for connecting the people and systems around biomedical engineering to better ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... May 19, 2020 , ... Experienced periodontist in Eden Prairie, ... implants and bone grafting through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to ... to prepare a patient for dental implants, especially when the implants need to be ...
(Date:5/15/2020)... ... May 14, 2020 , ... Children with defective ... surgeries before becoming adults. The reason: there are no heart valve prosthetics ... need, the Department of Defense has awarded Draper, Boston Children’s Hospital and Seattle ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... research, is bringing together thousands of industry leaders, clinicians, research scientists, medical professionals ... plenary speakers, Carl June, MD, Director of the Center for Cellular Immunotherapies at ...
(Date:5/5/2020)... ... May 04, 2020 , ... Red Nucleus, ... sciences industry, today announced that Informa Training Partners, a life sciences training company ... Red Nucleus Boston, effective immediately. , “The name change solidifies a stronger presence ...
Breaking Biology Technology:
Cached News: