HOME >> BIOLOGY >> NEWS
Cellular killer also important to memory

CHAMPAIGN, Ill. -- A protein known primarily for its role in killing cells also plays a part in memory formation, researchers at the University of Illinois at Urbana-Champaign report. Their work exploring how zebra finches learn songs could have implications for treatment of neurodegenerative conditions such as dementia and Alzheimer's disease.

When activated, the enzyme caspase-3 triggers a synaptic process essential for memory storage, according to Graham R. Huesmann and David F. Clayton of the department of cell and developmental biology and of the U. of I. Beckman Institute for Advanced Science and Technology. Their article, which appears in the Dec. 21 issue of the journal Neuron, describes their findings, which provide "the first direct evidence of a change in the availability of activated caspase-3 protein in the brain during the process of memory formation."

Caspase-3 is best known for its role in a biochemical cascade that leads to apoptotic cell death. These new findings demonstrate that the enzyme acts differently under different conditions, and suggest that its regulation in the brain is more complex than previously thought. Huesmann and Clayton examined the brains of zebra finches after exposing the birds to tape recordings of the songs of other birds. They found an increase in the concentration of activated caspase-3 in post-synaptic sites of the auditory forebrain shortly after the birds were exposed to unfamiliar bird songs. Exposure to familiar songs caused no significant increase in the enzyme.

The researchers demonstrated that the activated form of caspase-3 is short-lived and highly localized, which may explain why the enzyme does not trigger apoptosis.

They also showed that activated caspase-3 is always present in brain cells, but that it is usually bound by an inhibitor, BIRC4. For a short time after the birds are exposed to novel songs, the inhibitor releases the activated caspase-3. The concentration of
'"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
21-Dec-2006


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular pathway yields potential new weapon in vaccine arsenal
4. Cellular cues identified for stroke recovery
5. Cellular traffic backups implicated in skeletal malformations
6. Cellular antennae on algae give clues to how human cells receive signals
7. Cellular scale drug delivery from the inside out
8. Cellular dumping site is not garbage after all
9. Cellular power plants also fend off viruses
10. Aphids make chemical weapons to fight off killer ladybirds
11. Revealed -- Mosquito genes that could be controlling the spread of killer viruses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, ... financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... platform that provides services to more than one dozen hospitals and surgery centers ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... salient features of seizure risk signals, usually based on variations of amplitude, frequency ... the only acceptable diagnostic methodology due to the complexity and variability of the ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the ... mobile, announces the launch of version 13.1. The new version extends FileWave’s mobile ... and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s version 13 ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today ... (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene expression ... also increased the cells’ ability to lodge into bone marrow. This research performed ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... providing proprietary interest to our methodology, processes, and diagnostic techniques. The patent ... extends Somnology’s IP rights including our proprietary sleep scoring methodology. The approval ...
(Date:5/31/2019)... (PRWEB) , ... May 30, 2019 , ... ... the first to demonstrate an efficient delivery system for the sustained release of ... The platelet-rich plasma-based gel system was able to deliver CM into the injured ...
(Date:5/15/2019)... ... ... Milton Hershey School® has named William Charles Ballough Harding ’78 the 2019 Alumnus ... is changing lives by creating solutions to global healthcare challenges through the development of ... founders – Milton and Catherine Hershey – who always hoped for Milton Hershey School ...
Breaking Biology Technology:
Cached News: