HOME >> BIOLOGY >> NEWS
Cellular pathway yields potential new weapon in vaccine arsenal

When a cell has to destroy any of its organelles or protein aggregates, it envelops them in a membrane, forming an autophagosome, and then moves them to another compartment, the lysosome, for digestion. Two years ago, Rockefeller University assistant professor Christian Mnz showed that this process, called autophagy, sensitizes cells for recognition by the immune system's helper T cells. But he didn't know how often this pathway is used or how efficient it is. Now, a new study published online today in the journal Immunity goes a long way toward addressing these questions and shows that the pathway is so common that it could be a valuable new way of boosting vaccine efficacy.

There are two types of T cells: Helper T cells encourage their counterpart, killer T cells, to hunt down and attack invading pathogens. T cells typically recognize antigens only once they're presented to them by major histocompatibility compex (MHC) scaffolding molecules on a cell's surface. Antigens on MHC class I molecules are recognized by killer T cells and had originally been thought to come only from sources inside a cell (proteins from the nucleus or other cellular part); those on MHC class II molecules are recognized by helper T cells and had been thought to come from sources outside the cell, such as fragments of dead, infected cells. But as Mnz discovered two years ago, an autophagy pathway allows intracellular antigens to be presented on MHC class II molecules.

Now Mnz, head of Rockefeller's Laboratory of Viral Immunobiology, and Dorothee Schmid, a graduate student in the lab, have shown that the autophagy pathway is far more widespread than they thought: They found that a surprising number of cells with MHC class II molecules on their surfaces used the autophagy pathway. In skin (epithelial) cells and two other types of immune cells (dendritic and B cells), 50 to 80 percent of the autophagosomes moved into the loading compartment for MHC class II molecules. "F
'"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
22-Dec-2006


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. Cellular message movement captured on video
3. Cellular cues identified for stroke recovery
4. Cellular killer also important to memory
5. Cellular traffic backups implicated in skeletal malformations
6. Cellular antennae on algae give clues to how human cells receive signals
7. Cellular scale drug delivery from the inside out
8. Cellular dumping site is not garbage after all
9. Cellular power plants also fend off viruses
10. New, more direct pathways from outside the cell-to-cell nuclei discovered
11. Penn researchers discover pathway that eliminates genetic defects in red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2019)... ... May 13, 2019 , ... ... 4th, at a very special Pre-EWMA 2019 event at Gothenburg’s Universeum Aquarium. Guests ... Trends, Opportunities and Innovations in Advanced Wound Care. , SmartTRAK’s Advanced Wound Care ...
(Date:5/8/2019)... ... May 07, 2019 , ... Modality ... invitation-only community for world-class CIOs, CTOs, and technology executives. Modality Solutions ... firm that guarantees confidence in a company’s cold chain. Subject-matter experts provide ...
(Date:5/8/2019)... Conn. and TORONTO (PRWEB) , ... May 08, ... ... growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified eClinical ... II and III clinical trials and observational studies. Axiom is a leading e-clinical ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 08, 2019 , ... ... collaboration solutions, announced today the launch of their app integration solution, CT Cloud ... business and contact-orientated applications while using CT Cloud Voice and Skype for Business ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, Inc. , a ... latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal tests called ... Rosland Franklin, an English chemist and X-ray crystallographer who made significant contributions to ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the ... services to veterinarians across the United States and Canada since 2004. The primary ... soft tissue injuries in the dog, cat, and horse. Recently, VetStem teamed ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has ... a team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led ... PhD, of the Department of Medical Laboratory Sciences and Deputy Provost, College of ...
Breaking Biology Technology:
Cached News: