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Certain gene variation associated with better mobility for older individuals who exercise

a mile or walking up 10 steps, as reported on 2 consecutive semi-annual interviews.

"In this cohort of older well-functioning men and women, a high level of physical activity was associated with the preservation of physical function. Although physical activity was associated with less mobility limitation for all ACE I/D genotypes, the improved risk benefit was significantly greater for those possessing the ID or DD genotypes compared with the II genotype. The physiological basis for these findings is uncertain. However, among the physically active participants, the II genotype was also associated with higher levels of total adiposity [body fat] and intermuscular thigh fat," the authors write.

" the magnitude of the effect is not so strong as to imply that those possessing the II genotype do not benefit from exercise. Further study is required to confirm these associations and understand their physiological basis," the authors conclude. (JAMA. 2005; 294:691698. Available pre-embargo to the media at www.jamamedia.org.)


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Contact: Karen Richardson
336-716-4587
JAMA and Archives Journals
9-Aug-2005


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