HOME >> BIOLOGY >> NEWS
Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening

Nice, France: Embryos that are selected out as abnormal can undergo chromosomal modifications, a scientist will tell the annual conference of the European Society of Human Genetics today. Ms Tsvia Frumkin, from the Racine IVF unit, LIS Maternity Hospital, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel, will tell the conference that her teams findings meant that the results of preimplantation genetic screening (PGS) for chromosomal abnormalities were not always reliable and should be interpreted with caution.

PGS is offered to women with recurrent IVF failures as well as repeated miscarriages. It is based on the concept that the entire chromosomal constitution of an embryo can be represented by a single cell, which is removed from the embryo. If one biopsied cell is found to be abnormal, there is a 90% chance that the rest of the embryo is also abnormal or mosaic, where two or more cells with different chromosomal constitution exist in a single embryo.

Ms Frumkin analysed 8 cell embryos at day 3 of development using the FISH (fluorescence in situ hybridization) technique. Two cells from each embryo were analysed, and between 5 and 9 chromosomes were investigated. The abnormal embryos were re-analysed on day 5, using the same method. By comparing FISH results of day 5 embryos to the abnormal results of the same embryos on day 3, we could elucidate the origin of the chromosomal aberrations and follow different chromosomal modifications as they occurred during preimplantation period. The timing is significant because embryos used in IVF are normally transferred at between 3 and 5 days old, says Ms Frumkin.

We found that embryos which were abnormal on day 3 demonstrated a high rate of mosaicism However, on day 5 some of them had undergone self-correction into normal embryos. Others kept the same abnormalities, while some had acquired additional chromosomal abnormalities, she says.

Following the research, Ms Frumki
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society of Human Genetics
18-Jun-2007


Page: 1 2

Related biology news :

1. Changes in west coast marine ecosystems significant
2. Changes in amino acids in the 1918 influenza virus cut transmission
3. Changes in dietary protein may override inherited skeletal abnormalities
4. Symposium Changes on Earth honors Yale Geologist Robert Berner
5. Changes to in utero environment may alter onset of cancer, U of T study
6. Changes in reef latitude
7. Changes to embryos can elicit change in adult fish
8. Changes in technique can reduce radiation dose in CT examination
9. Changes in community size affect the outcome of competition
10. Support for chromosomal theory of cancer found in cancers development of drug resistance
11. Speeding the search for elusive chromosomal errors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: