HOME >> BIOLOGY >> NEWS
Changes in dietary protein may override inherited skeletal abnormalities

Eating a diet with either high or low amounts of protein may override certain inherited developmental malformations of the skeleton, according to a new report in the December issue of the journal Cell Metabolism, published by Cell Press. Such so-called skeletal dysplasiae include more than 200 disorders of bone growth that lead to skeletal disproportions.

A study of mice led by Gerard Karsenty of Columbia University now uncovers new details of the molecular machinery that governs bone formation. Specifically, the researchers found that loss of a gene that is mutated in patients with a condition called neurofibromatosis (NF) type I causes an abnormal increase in activity of genes responsible for manufacturing bone.

The researchers also found a more general link between dietary amino acidsthe building blocks of proteinsand normal bone development. That result raised the possibility that changes in nutrition may, in some cases, offer a simple treatment for skeletal dysplasiae, according to the researchers, who conducted the work primarily at Baylor College of Medicine.

These results not only provide a molecular basis for NF skeletal manifestations, Karsenty said, but also identify a hitherto unanticipated connection between amino acid intake and skeletal development.

Neurofibromatosis type I, a disease which affects an estimated 1 in 3000 to 4000 people in the United States, is caused by loss of function of a gene encoding neurofibromin (NF1). In addition to well-described tumors of the nervous system, the condition in patients often includes skeletal abnormalities that have not been well understood, the researchers said.

As a result of the paucity of molecular knowledge of how neurofibromin affects bone biology, the only available treatment for these often debilitating manifestations remains surgery, Karsenty said.

To further elucidate NF1s skeletal role, Karsentys team generated mice that lacked the gen
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
5-Dec-2006


Page: 1 2

Related biology news :

1. Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening
2. Changes in west coast marine ecosystems significant
3. Changes in amino acids in the 1918 influenza virus cut transmission
4. Symposium Changes on Earth honors Yale Geologist Robert Berner
5. Changes to in utero environment may alter onset of cancer, U of T study
6. Changes in reef latitude
7. Changes to embryos can elicit change in adult fish
8. Changes in technique can reduce radiation dose in CT examination
9. Changes in community size affect the outcome of competition
10. New $1.16 million study investigates how dietary iron is used by cells
11. ASU research shows connection between testosterone, dietary antioxidants and bird coloration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, ... have entered into license agreements with Housey Pharma’s HMI subsidiary to gain access ... J&J have annual Research and Development spending in excess of US $10 billion. ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is ... medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. ... chain for more than 10 years. Early in the COVID-19 crisis, we identified ...
(Date:7/18/2020)... , ... July 17, 2020 , ... Commercial launch readiness ... pharma’s ability to discover a COVID cure or vaccine, the global economic downturn will ... price pressure is not going away and capturing full value from every product launch ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem ... 200 million stem cells. Depending on the patient's condition, treatment may be offered IV, ... die having some form of Alzheimers dementia, and the incidence continues to increase as ...
(Date:6/28/2020)... , ... June 25, 2020 , ... The Indoor Lab, ... of Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy ... , A Safe Space™ enabled business will provide a health performance index system ...
Breaking Biology Technology:
Cached News: