HOME >> BIOLOGY >> NEWS
Channel protein converts vibrations to electrical signal

bound the tips of the cilia, where the mechanically activated channels were known to be located. This localization of TRPA1 changed, however, when the researchers treated the hair cells with a chemical that damages the mechanically-sensitive signaling pathway.

Other researchers had recently found that if a hair cell's tip links are chemically separated, the tip link protein, cadherin 23, is removed from the cilia within minutes. According to Corey, this suggests that once a hair cell senses that its signaling complex has been damaged, it rapidly recycles the components of that pathway so they can be reused or replaced. "So we said, look, if the tip-link protein goes away when you separate the tip links, maybe other parts of the transduction machinery will go away. And if TRPA1 is the right channel, it should go away." In fact, TRPA1 did disappear when the tip links were removed further evidence for a role in that signaling pathway.

The next step was to determine how cells functioned without TRPA1, which the researchers tested by interfering with the production of the protein in both zebrafish embryos and hair cells from mice. To test function, the researchers bathed the embryos or the mouse cells in a solution containing a dye either yellow or red that can pass through the ion channel. The dye entered the normal cells, accumulating and causing them to glow. In cells where TRPA1 had been reduced, however, less dye was able to enter the cells suggesting that without TRPA1, there was no channel for the molecule to pass through.

"A more direct way to measure the mechanical sensitivity of the cell is to measure the electrical response that it gives when you stimulate the cell," Corey said. By putting a microelectrode on the mouse hair cells, the scientists could directly measure the amount of current flowing through the channels. With lower levels of TRPA1, current flow was diminished. In zebrafish embryos, they measured the voltage inside
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
13-Oct-2004


Page: 1 2 3 4 5

Related biology news :

1. ResearchChannel boosts awareness of vital research with video production program
2. ResearchChannel awards matching funds for video production
3. ResearchChannel expands delivery for its extensive online video library
4. Penn researchers discover how key protein stops inflammation
5. UCF research links proteins, stem cells and potential Alzheimers treatment
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. Discovery of new protein could provide new understanding of male fertility
8. Unlocking proteins from their cellular shell
9. Altering a protein makes mice less fearful
10. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
11. MicroRNA works with Ago2 protein to regulate blood cell development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2020)... ... March 20, 2020 , ... ImStem Biotechnology, ... cell (ESC) derived mesenchymal stem cells (hES-MSC), through a proprietary method using a ... autoimmune, and rare orphan diseases, today announced that the U.S. Food and Drug ...
(Date:3/13/2020)... ... March 13, 2020 , ... ... Inc. to be the exclusive distributor of the Louisville-based company’s orthobiologics portfolio. Under ... education expertise to distribute Vivorte’s calcium phosphate-based bone allograft (Trabexus) and calcium phosphate-based ...
(Date:3/5/2020)... ... March 05, 2020 , ... ... partnership agreement with Phoenestra GmbH to accelerate Cytonus’ existing products and to expand ... Diego, California. Phoenestra is a biotech company located in Austria. , Phoenestra ...
Breaking Biology News(10 mins):
(Date:4/1/2020)... JOLLA, Calif. (PRWEB) , ... March 31, 2020 , ... ... Jolla Institute for Immunology (LJI), announced today that they will use Carterra’s proprietary LSA™ ... move therapeutic candidates to the clinic as early as this summer. , La ...
(Date:3/19/2020)... ... March 17, 2020 , ... ... collaboration agreement with pioneering gene circuit company Senti Biosciences, Inc. (Senti) to ... and other solid tumor indications. The collaboration will leverage RoosterBio’s human mesenchymal ...
(Date:3/10/2020)... , ... March 10, 2020 , ... Ortho Clinical Diagnostics, ... innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen in ... is cleared to run on ORTHO VISION® and ORTHO VISION® Max in the United ...
(Date:3/4/2020)... ... ... This month, Cognosante will make its annual appearance at the HIMSS Global Health Conference ... that align with the HIMSS annual theme, “Be the Change.” , Cognosante’s presence ... From Interoperability and HIE to Cloud Computing and BPO ...
Breaking Biology Technology:
Cached News: