HOME >> BIOLOGY >> NEWS
ChemGenex reports successful personalized dosing of Quinamed at ASCO

MELBOURNE, Australia, and MENLO PARK, California U.S.A. (June 4, 2007). ChemGenex Pharmaceuticals (ASX: CXS, NASDAQ: CXSP) announced today the presentation of data from its Quinamed (amonafide dihydrochloride) phase 1/2a dose-escalation study, designed to identify a genotypically optimised dose of Quinamed in heavily pre-treated patients with a variety of solid tumors. The key outcomes from this study were (i) demonstration that dose level could be optimised according to patient genotype, (ii) the drug was well tolerated, with predictable and manageable side effects, and (iii) there was evidence of anticancer activity in several solid tumor types.

Dr. John Kuhn of the University of Texas Health Science Center in San Antonio, TX, along with the investigators at Sarah Cannon Cancer Center, TN and University of Louisville, KY discussed the data in an oral presentation at the American Association of Clinical Oncology (ASCO) 43rd Annual Meeting in Chicago, Illinois.

The clinical activity of amonafide against a variety of cancers has long been recognized, but development has been hampered by the unpredictable side effect profile for patients said Dr Kuhn. We are excited by the new opportunities that personalized dosing of Quinamed offers for a range of solid tumor patients who have developed resistance to existing therapies.

Highlights of the presentation included:

  • Confirmation that genotyping of patients prior to treatment allows for optimized personalized dosing and improved drug tolerance.
  • Patients with rapid and intermediate acetylator genotypes (who more rapidly metabolize the drug to the acetylated derivative associated with side effects) achieved a maximum tolerated dose (MTD) of 320 mg/m2 of Quinamed weekly, whilst patients with slow acetylator genotypes achieved an MTD of 400 mg/m2 of Quinamed weekly (three weeks on treatment followed by one week off treatment, repeated). Using these dosing regimens, 64% of
    '"/>


Contact: Joan Kureczka
jkureczka@comcast.net
415-821-2413
Kureczka/Martin Associates
4-Jun-2007


Page: 1 2

Related biology news :

1. ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
2. 1 month post launch, Interactive Autism Network reports 13,000 participants
3. Biosite reports on presentation of preliminary data from sepsis program
4. Biolex reports potential for more potent, efficacious antibodies in Nature Biotechnology
5. Orexigen reports positive phase II results for Excalia Combination-Therapy to treat obesity
6. Dinosaurs climate shifted too, reports show
7. The New England Journal of Medicine reports data on eculizumab for the treatment of PNH
8. Portion distortion may contribute to expanding waistlines, study reports
9. Study reports findings on lung cancer death rates in never smokers
10. Breast implants not associated with cancer risk, study reports
11. Paper reports discovery of virus implicated in genetics of prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... Switzerland (PRWEB) , ... June ... ... provider of enterprise software solutions for biopharmaceutical R&D, today announced that it ... company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... software-driven clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics ... inhibitor, in hospitalized patients with severe COVID-19. This is the first study of ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, ... a UK supplier and manufacturer of innovative portable renewable energy equipment, have announced ... fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands ... , Known as MediVet Biologics since its formation in 2016, the company is ... Animal Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products ... three different materials for use with CRM, neurostimulation, vascular, and related devices. , ... meet specific design requirements, performance, and cost criteria; especially where solid wire is ...
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... ... ... fast-growing provider of cloud-based software for the life sciences industry, today announced ... and presentation platform designed specifically for Medical Science Liaisons (MSLs) and other ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
Breaking Biology Technology:
Cached News: