Chemical that triggers hibernation may protect muscles

A phenomenon known as ischemic preconditioning (IP), in which blood flow to muscle is reduced and then restored, has previously been shown to increase muscle function, especially in the heart. A new study published online June 6, 2005 in Muscle & Nerve explores the link between the protective effect of IP in skeletal muscles and the substance that triggers hibernation. The journal is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/mus.

During certain types of vascular or reconstructive surgery, it is sometimes necessary to block blood flow, which may cause tissue damage. This problem might potentially be alleviated if a pharmacological substance was able to achieve IP. Hibernation in mammals is thought to confer cardiac benefits similar to IP. Researchers led by Jinback Hong, Ph.D. of the department of biomedical engineering at the University of Minnesota in Minneapolis, MN, set out to explore whether pretreatment with the chemical that induces hibernation (hibernation induction trigger or HIT) would have the same protective effect as IP in skeletal muscles and the mechanism by which this effect might occur. The study involved removing muscle tissue from 77 pigs, and subjecting it to hypoxia (a reduction of oxygen supply) for 90 minutes, followed by 120 minutes of reoxygenation. The muscles were then divided into several groups that were treated with plasma from hibernating woodchucks (HWP), plasma from woodchucks active in the summer (SAWP), HWP plus naloxone (an opiate receptor antagonist), HWP plus potassium channel blocker, and various control groups. After 30 minutes and 120 minutes of reoxygenation, the HWP group showed significantly more muscle activity, as measured by twitch force, than the other groups. The HWP group was also not significantly different than a control group that was not subjected to hypoxia.

In discussing the effect of seru

Contact: David Greenberg
John Wiley & Sons, Inc.

Page: 1 2

Related biology news :

1. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
2. American Chemical Society meets Aug. 19-23 in Boston
3. American Chemical Societys Weekly PressPac -- Aug. 1, 2007
4. News tips from ACS Chemical Biology
5. American Chemical Societys Weekly PressPac -- July 25, 2007
6. American Chemical Societys Weekly PressPac -- July 18, 2007
7. American Chemical Societys Weekly PressPac -- July 11, 2007
8. Wiley extends publishing partnership with the American Institute of Chemical Engineers
9. American Chemical Societys Weekly PressPac -- June 27/July 3, 2007
10. News tips from ACS Chemical Biology
11. American Chemical Societys Weekly PressPac -- June 20, 2007

Post Your Comments:

(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed ... well-being of our attendees, staff, and the public. We remain committed to creating ... ways to collaborate virtually,” said Julie Sutcliffe, President of WMIS. , ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... barcode and RFID labeling software developer and solutions provider, today reported that ... improved labeling accuracy and compliance by 100%, resulting in greater efficiency for ...
(Date:5/28/2020)... , ... May 27, 2020 , ... CrucialTrak, a global ... with New Jersey-based Critical Environments Group (CEG) to market and sell its complete line ... data center and IT environment infrastructure optimization solutions . , Brett Mason, ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing System (TIPS), ... membership, recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor ... seating, cafeteria tables, book trucks and carts at discounted pricing without the delay ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading provider of sensor ... of all types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ ... enabled business will provide a health performance index system that scores all aspects of ...
Breaking Biology Technology:
Cached News: