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Chicken genomic sequence yields insight into vertebrate evolution

> Similar results were obtained for another imprinted gene cluster, the region containing the IGF2 and H19 genes, by another group of investigators led by Hiroyuki Sasaki, Ph.D., from the National Institute of Genetics in Mishima, Japan. Sasaki and colleagues found that most of the imprinting control elements from this region that are present in mammals were not found in chicken. Furthermore, the chicken genes were expressed from both the paternal and maternal alleles, in contrast to the monoallelic expression pattern in mammals. "Our findings," Sasaki said, "show that the elements associated with imprinting probably evolved after the divergence of mammals and birds."


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Contact: Maria A. Smit
smit@cshl.edu
516-422-4013
Cold Spring Harbor Laboratory
8-Dec-2004


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