HOME >> BIOLOGY >> NEWS
Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab

Using a compound from a centuries-old Chinese traditional medicine, Yale University researcher Dr. Craig Crews has been able to prevent the formation of kidney-destroying cysts in a mouse model of polycystic kidney disease. This ability holds out hope for what would be the first treatment, other than kidney transplant or frequent dialysis, for one of the most lethal of all kidney diseases worldwide.

Dr. Crews described the functioning of the compound at Experimental Biology 2007 in Washington, DC. His presentation on April 29 is part of the scientific program of the American Society for Biochemistry and Molecular Biology.

Triptolide is derived from a Chinese medicinal herb, named Lei Gong Teng, which has been used in traditional medicine to treat cancer, inflammation, and auto-immune diseases and, more recently, also has been tested in Phase I clinical trials as an anti-tumor agent.

This study, with mice bred to have a disease like human polycystic kidney disease, used triptolide with a less toxic concentration than that used in cancer chemotherapy trials. At that level, the compound marked reduced cyst formation in the mice compared to genetically similar mice not taking the compound.

During normal kidney development, cells lining the kidney tubules continue growing and dividing until they receive a signal that the tubule is fully formed. The switch that turns on that signal consists of the growth regulatory proteins PKD1 and PKD2, located on hair-like cilia in the lining of the developing tubules. When urine begins flowing through the tubules, the flow bends the cilia that sets off the signal that no more growth is needed.

In people who have a mutation in one of these growth regulatory proteins, however, the message to stop growing never gets delivered, even when urine is flowing and the cilia are bending. It is as if the phone is ringing but the cell can't hear it. So, never sensing a signal to stop,
'"/>

Contact: Sylvia Wrobel
ebpress@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
29-Apr-2007


Page: 1 2

Related biology news :

1. Lifting Chinese tiger trade ban a death sentence for wild tigers say WWF and TRAFFIC
2. Active ingredient in common Chinese herb shown to reduce hypertension
3. Genomatix appoints distributor for the growing Chinese market
4. Forest service researchers test Chinese tallow tree for use in building materials
5. Self-esteem falters among Chinese teens
6. Scientists discover reason behind ear canal in Chinese frog: Ultrasonic communication
7. Rare Chinese frogs communicate by means of ultrasonic sound
8. Language barrier just one roadblock to diabetes control for Chinese-speaking immigrants
9. Rutgers entomologist honored by Chinese Academy of Sciences
10. Chinese-American Frontiers of Science Nov. 2 - 4
11. Compound from Chinese medicine shows promise in head and neck cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... (PRWEB) , ... August 21, 2019 , ... ... E. coli cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, ... Formerly a member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than ...
(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures ... Food and Agriculture practice, a new unit dedicated to building 100 companies over the ... raw materials and supply chains. , Deep Science Ventures was founded to create ...
(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® ... they have opened a Customer Experience Center (CEC) and office in Munich, Germany. ... office. , The Munich CEC will be a place for researchers throughout Europe ...
Breaking Biology News(10 mins):
(Date:9/4/2019)... N.J. (PRWEB) , ... September ... ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... Ph.D., Director, Science & Technology will present at the upcoming Nordic Life ...
(Date:8/29/2019)... ... August 28, 2019 , ... DuPont Nutrition & Biosciences ... attendees at the International Baking Industry Expo, September 8 to 11, in booth ... efficiency to cost and waste reduction and from maintaining freshness throughout shelf life ...
(Date:8/27/2019)... ... August 27, 2019 , ... Modality ... announce it has promoted Consulting Engineer, Robert Battista, to Senior Consulting engineer. , ... of onboarding and mentoring new engineers as well as the creation of additional ...
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
Breaking Biology Technology:
Cached News: