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Chromosome 16 publication fulfills DOE's human genome commitment

lves into the 78.8 million bases, or letters of DNA code, on Chromosome16, home to 880 genes including those implicated in the development of breast and prostate cancer, Crohn's disease and adult polycystic kidney disease. With the advancements accrued over the last five years at the JGI Production Genomics Facility, sequence is now being produced at a rate of 2.5 billion bases per month--or the equivalent of a human genome in just five weeks.

JGI researchers characterized the many regions on chromosome 16 that have been copied to other places within the chromosome, and even to the other chromosomes, a phenomenon known as segmental duplication. They compared these human sequences to regions conserved over time in other vertebrate genomes, including chimpanzee, dog, mouse, rat, chicken and pufferfish to shed light on changes that have occurred since the last common ancestor, ranging from five million to 400 million years ago.

The effort to complete the sequence of chromosome 16 was led by JGI researchers Joel Martin and Len Pennacchio and included over 100 researchers from the partnership of Los Alamos, Lawrence Berkeley and Lawrence Livermore national laboratories, as well as the Stanford Human Genome Center, the Department of Genome Science of the University of Washington, and Children's Hospital in Oakland, CA. In addition to the research article in Nature, a large color poster highlighting biologically important elements of all three chromosomes sequenced by JGI along with DOE's other contributions to genomics is featured in the publication.

"The success of the Human Genome Project was enabled by the selfless dedication and creativity of thousands of scientists around the world," said Aristides Patrinos, Associate Director of Science for Biological and Environmental Research, who has led the DOE genomics effort since 1995. "It has been an honor and a thrill to the DOE team to have played such a pivotal role in the launching and successf
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Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
22-Dec-2004


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