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Chromosome 16 publication fulfills DOE's human genome commitment

ul completion of this most noble of human undertakings."

Chromosome 16 was the original focus of DNA repair gene studies initiated at DOE's Los Alamos National Laboratory in 1988. Additional interest stemmed from the discovery of genes on chromosome 16 implicated in the detoxification and transport of heavy metals.

Genome Effort Began in 1987

The Department of Energy and its predecessor agencies for decades have sponsored genomics research, including basic studies of DNA replication, damage, and repair, and the consequences of radiation-induced heritable mutations. In 1987, recognizing its pioneering contributions to discovery class science, a federal report recommended DOE assume a leadership role in an expansive multidisciplinary undertaking to map and sequence the human genome. Thus, between 1988 and 1989, three genome research centers were established at Lawrence Berkeley, Lawrence Livermore, and Los Alamos national laboratories. These were combined in 1997 into the DOE Joint Genome Institute (JGI).

With this genomics powerhouse now recognized, JGI continues to advance the frontiers of genome sciences through the advent of the Community Sequencing Program (CSP). The CSP will provide a world-class sequencing resource for the expanding diversity of disciplines--geology, oceanography, and ecology, among others--that can benefit from the application of genomics. Priority is given to sequencing organisms that are relevant to DOE missions.

"The Human Genome Project stands as the crown jewel and capstone of 20th century biology," said Charles DeLisi, Arthur G. B. Metcalf Professor of Science and Engineering at Boston University. "The Department of Energy's role as the project's prime mover, and its continued leadership throughout the course of the project, reminds us of the enormous wealth of talent in the DOE national laboratory system--talent that, in the case of the HGP, has served not just the nation, but all the peo
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Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
22-Dec-2004


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