HOME >> BIOLOGY >> NEWS
Chromosome deletion predicts aggressive neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer.

Edward F. Attiyeh, M.D., a pediatric oncology fellow at The Children's Hospital of Philadelphia, reported on a study of 915 patients in a presentation today at the American Society of Clinical Oncology annual meeting in Orlando, Fla. The patients were children with primary neuroblastoma treated at Children's Oncology Group (COG) centers. The COG is a National Institutes of Health-funded multicenter clinical research organization that supports clinical trials for pediatric cancer patients.

Neuroblastoma, which accounts for 10 percent of all pediatric cancers, often occurs as a solid tumor in a child's abdomen or chest. Some cases of neuroblastoma are low risk, and resolve after surgeons remove the tumor. Other cases are more aggressive, and are more likely to resist initial treatment, or to cause a relapse. Identifying the correct risk level allows doctors to treat aggressive cancers appropriately, while not subjecting children with low-risk cancer to overtreatment.

Oncologists know that amplification, an abnormal increase in the number of copies, of a cancer-causing gene called MYCN heralds a high-risk, aggressive cancer. However, a significant number of neuroblastomas are aggressive without having amplified MYCN. "The deletion of genetic material on chromosome 11 may account for a significant percentage of these high-risk neuroblastomas," said Dr. Attiyeh.

It is unknown what causes the deletion of genes on chromosome 11, at a location designated chromosome 11q23. However, the loss of material at that site apparently removes the protective effect of a tumor suppress
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
16-May-2005


Page: 1 2

Related biology news :

1. Chromosome glue repairs damaged DNA
2. Chromosome rearrangements not as random as believed
3. Chromosome regions containing genes related to alcohol addiction affect drinking behavior in smokers
4. Chromosome four contains genes that affect drinking behaviors in smokers
5. Chromosome 16 publication fulfills DOEs human genome commitment
6. Teens with deletion syndrome confirm genes role in psychosis
7. Gene predicts better outcome as cortex normalizes in teens with ADHD
8. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
9. Major study predicts grim future for Europes seas
10. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
11. NASA predicts nongreen plants on other planets

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Chromosome deletion predicts aggressive neuroblastoma

(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... smart wallets is underway to early access pre-order customers. ... includes usage at retail outlets including Walmart, Target, AT&T, ... report Wocket was accepted at all outlets and very ...
(Date:3/26/2015)... March 26, 2015 The Granite ... recreation and athletic club, today announced it has implemented ... freedom of movement for members and staff, while restricting ... comprehensive process, we selected FST,s IMID Access system because ... for our members and staff, in addition to unparalleled ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
(Date:4/24/2015)... 24, 2015 /CNW Telbec/ - Mirego, leader in mobile strategies ... of three mobile app extensions for the all new Apple ... clients, Familiprix, OMSignal and MediaMiser, these extensions will reinvent the ... designed specifically for wrist use.  Available today ... a highly customizable tactile smartwatch that makes for an excellent ...
(Date:4/23/2015)... 23, 2015 Athena San Diego, an ... executive women in San Diego’s technology and life science ... Pinnacle Awards at their Gala on April 30, 2015 ... now at http://athenasd.org/events/ , The Pinnacle Awards ... San Diego vision of fostering networking, risk taking and ...
(Date:4/23/2015)... -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... results before the Nasdaq market opens on Thursday, April ... and webcast to discuss its financial results and provide ... 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... dialing 866-952-1906 (US) or 785-424-1825 (International) using the conference ...
(Date:4/23/2015)... LONDON , April 23, 2015 ... Medical Equipment   Report Details   ... reach a value of $101.3 billion in 2015 and will ... Strong growth in the healthcare sectors around the world and ... the key growth factors in the global healthcare packaging ...
Breaking Biology Technology:Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10
Cached News: