HOME >> BIOLOGY >> NEWS
Chromosome deletion predicts aggressive neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer.

Edward F. Attiyeh, M.D., a pediatric oncology fellow at The Children's Hospital of Philadelphia, reported on a study of 915 patients in a presentation today at the American Society of Clinical Oncology annual meeting in Orlando, Fla. The patients were children with primary neuroblastoma treated at Children's Oncology Group (COG) centers. The COG is a National Institutes of Health-funded multicenter clinical research organization that supports clinical trials for pediatric cancer patients.

Neuroblastoma, which accounts for 10 percent of all pediatric cancers, often occurs as a solid tumor in a child's abdomen or chest. Some cases of neuroblastoma are low risk, and resolve after surgeons remove the tumor. Other cases are more aggressive, and are more likely to resist initial treatment, or to cause a relapse. Identifying the correct risk level allows doctors to treat aggressive cancers appropriately, while not subjecting children with low-risk cancer to overtreatment.

Oncologists know that amplification, an abnormal increase in the number of copies, of a cancer-causing gene called MYCN heralds a high-risk, aggressive cancer. However, a significant number of neuroblastomas are aggressive without having amplified MYCN. "The deletion of genetic material on chromosome 11 may account for a significant percentage of these high-risk neuroblastomas," said Dr. Attiyeh.

It is unknown what causes the deletion of genes on chromosome 11, at a location designated chromosome 11q23. However, the loss of material at that site apparently removes the protective effect of a tumor suppress
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
16-May-2005


Page: 1 2

Related biology news :

1. Chromosome glue repairs damaged DNA
2. Chromosome rearrangements not as random as believed
3. Chromosome regions containing genes related to alcohol addiction affect drinking behavior in smokers
4. Chromosome four contains genes that affect drinking behaviors in smokers
5. Chromosome 16 publication fulfills DOEs human genome commitment
6. Teens with deletion syndrome confirm genes role in psychosis
7. Gene predicts better outcome as cortex normalizes in teens with ADHD
8. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
9. Major study predicts grim future for Europes seas
10. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
11. NASA predicts nongreen plants on other planets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... ... 07, 2018 , ... The awards were presented by BioInformatics ... The event was attended by 150 industry executives from leading life science companies ... The winners were determined by responses to an online ballot completed by almost ...
(Date:11/3/2018)... ... November 01, 2018 , ... Emerging Trends in ... New Opportunities, **Presented by FDAnews**, Dec. 6, 2018 – Kleinfeld, Kaplan & Becker, ... pricing for Emerging Trends in Medical Device Regulation and Quality ends on Thursday, ...
(Date:10/31/2018)... N.C. (PRWEB) , ... October 30, 2018 , ... ... of Brad Heidinger to Director of Operations. With more than 20 years of ... proven visionary leadership in the biomanufacturing industry. Heidinger joins Azzur from ImmunoReagents, a ...
Breaking Biology News(10 mins):
(Date:11/3/2018)... ... 01, 2018 , ... Come to Princeton Nov. 14 and ... Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on using data ... should clinical research industry stakeholders keep in mind when implementing and managing risk-based ...
(Date:10/31/2018)... Calif. (PRWEB) , ... October 30, 2018 , ... ... experimental manipulation continue to be a very important aspect of experimental biology. Reproducibility ... reliability of experimental data. Despite of choosing the appropriate assay type, there are ...
(Date:10/24/2018)... ... 2018 , ... uBiome, the leader in microbial genomics, announces ... Stephenson Chair of Data Science, and Professor in the Department of Biomedical Engineering ... and doctors from around the world, Dr. Bourne will bring to uBiome his ...
(Date:10/18/2018)... ... 2018 , ... With rapid technological advances in the fertility field, increasing numbers ... women facing a cancer diagnosis requiring chemotherapy or removal of an ovary, most women ... put, they do not want to get pregnant now but may want to in ...
Breaking Biology Technology:
Cached News: