HOME >> BIOLOGY >> NEWS
Chronic neuropathic, 'phantom' pain comes from affected nerve and spinal cord, not brain

BETHESDA, MD By some accounts, chronic pain affects nearly 100 million Americans from such varied causes as arthritis, sciatica, cancer, diabetes. Most forms of pain result from identifiable causes which serve the "good" purpose in warning of a real physical problem that needs attention, or rest.

Another kind of chronic pain may start with a specific injury, surgery or disease event, but may linger for weeks or even years beyond any useful protective function. Such events range from shingles to open-heart surgery where up to half the patients suffer long-term pain, breast removal (sometimes even lumpectomies), or in the most drastic cases, spinal injury or amputation.

Such "neuropathic pain" is particularly vexing and difficult to treat because there's no agreed location or physiological mechanism to target for therapy. New research from the University of Alberta, Canada appearing in the Journal of Neurophysiology reported that the place to look is between the nerves that are producing the pain and the spine, rather than from the spine to the brain, according to the senior author, Peter A. Smith.

The paper, "Sciatic chronic constriction injury produces cell-type specific changes in the electrophysiological properties of rat substantia gelatinosa neurons," is in the online Journal of Neurophysiology, published by The American Physiological Society. Research was by Sridhar Balasubramanyan, Patrick L. Stemkowski, Martin J. Stebbing and Peter A. Smith, University of Alberta, Canada; Stebbing is also at RMIT University, Bundoora, Australia.

Importance of identifying peripheral nerves as key target

Marshall Devor, a professor at the Institute of Life Sciences, and at the Center for Research on Pain, Hebrew University, Jerusalem, said "the results reported in this paper are quite optimistic in terms of the prospects for finding future methods of treatment. First," he said, "because if the problem is in the spine or the bra
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
5-Jun-2006


Page: 1 2 3 4

Related biology news :

1. Chronic fatigue -- clues in the blood
2. Chronically sleep deprived? You cant make up for lost sleep
3. Chronic jet-lag conditions hasten death in aged mice
4. Chronic oil pollution takes toll on seabirds along South American coast
5. Chronic drinking and smoking cause both separate and interactive brain injury
6. Chronic stress might harm women more than it does men
7. Chronic stress accelerates atherosclerosis following angioplasty procedure
8. Chronic inflammation caused by too little stomach acid leads to gastric cancer
9. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
10. Skin rash actually signifies better outcomes for pancreatic and lung cancer patients
11. Arctic spring comes weeks earlier than a decade ago

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy ... President of Clinical Operations. She brings years of expertise in establishing and leading ... professional foundation as a licensed occupational therapist, through a variety of leadership roles ...
(Date:5/23/2017)... ... May 23, 2017 , ... Customers often prefer ... again and again. METTLER TOLEDO has released two new videos that show how ... integration of the ACT350 into Siemens and Allen Bradley PLCs is easy and ...
(Date:5/22/2017)... ... May 22, 2017 , ... Cancer ... exhibiting in booth B2 at the Association for Pathology Informatics Annual Summit ... In addition to demonstrating its Cancer Diagnostic Cockpit and Consultation Portal, Inspirata will ...
(Date:5/19/2017)... ... 2017 , ... In response to the strong base of evidence supporting the ... the release of their Gait Trainer 3 with an Integrated Music Therapy option. This ... aid in rehabilitating individuals with cerebral palsy, traumatic brain injury, stroke and Parkinson’s disease. ...
Breaking Biology Technology:
Cached News: