HOME >> BIOLOGY >> NEWS
Cincinnnati scientists pursue new target for asthma treatment

Cincinnati scientists have found further evidence that certain defensive white cells in the body cause or play a major role in the symptoms experienced by asthma patients.

Their findings, scientists say, could lead to the identification of a new treatment "target" to help the estimated 17 million asthma sufferers in the United States.

The scientists, at the University of Cincinnati (UC) Academic Health Center and Cincinnati Children's Hospital Medical Center, report their results in the October 31, 2006 edition of the Proceedings of the National Academy of Sciences.

Working with genetically altered mice, the Cincinnati researchers studied a group of cells called eosinophils. Originally evolved to defend the body against parasite infection, a problem no longer common in the Western world, eosinophils are known to accumulate during allergic responses--and especially in mucous in the lungs of asthma patients.

"Researchers have been looking at the role of eosinophils in asthma for decades," says research associate and first author Patricia Fulkerson, PhD. "Since people in the Western world don't have parasites in their guts to the extent they used to, the question is what eosinophils do now?"

"Previous studies linking eosinophils to asthma were done in single models," Fulkerson explains. "We increased the power of our study by looking at multiple models, and by doing that we show a strong role for eosinophils in mucous production in asthma."

The researchers, led by Professor Marc Rothenberg, MD, PhD, of UC College of Medicine and Cincinnati Children's Hospital Medical Center, also showed that eosinophils contribute to the recruitment of the immunity-regulating proteins known as cytokines, a process that allows mucous to accumulate in the lung.

"Previously most scientists looked at one model at a time--eliminating as many eosinophils as possible, inducing each model with asthma, and then watching what ha
'"/>

Contact: David Bracey
david.bracey@uc.edu
513-558-4559
University of Cincinnati
20-Nov-2006


Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2020)... PRUSSIA, Pa. and CAMBRIDGE, Mass. (PRWEB) , ... ... ... to solving complex problems for life sciences companies and government agencies, announced that ... life sciences hubs in the country. Tunnell’s Cambridge office will be in the ...
(Date:1/27/2020)... , ... January 27, 2020 , ... On Thursday, February ... Solutions Life Sciences, Reed Tech and Richard Castle, Global Account Manager Medical ... discussing the procedure, other topics include EU MDR timing deadlines, best practices in creating ...
(Date:1/24/2020)... ... January 24, 2020 , ... Shoreline Biome , a microbiome research ... announced that the company will debut a novel new DNA isolation kit at the ... product, Shoreline Biome's Rapid Prep kit, is a fast and easy-to-use kit designed for ...
Breaking Biology News(10 mins):
(Date:1/10/2020)... ... January 09, 2020 , ... ... Development establishes benchmarks for the vendor qualification process, a critical element of ... process volume and complexity of the vendor qualification process creates delays in initiation ...
(Date:1/8/2020)... ... January 08, 2020 , ... RMA ... couples and individuals grow their family, has announced that five of their Board-Certified ... Connolly. Since 1991, the renowned publishing company Castle Connolly has compiled ...
(Date:1/7/2020)... (PRWEB) , ... January 06, 2020 , ... ... Control, today announced its expansion into whole-home smart lighting with two new products: ... Switch unlocks the ability for homeowners and homebuilders to affordably add high-end smart ...
(Date:12/30/2019)... ... December 30, 2019 , ... Leak Detection ... for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is pleased to ... compliant software program specific to the custom-built helium leak testing systems it designs ...
Breaking Biology Technology:
Cached News: