HOME >> BIOLOGY >> NEWS
Clam embryo study shows pollutant mixture adversely affects nerve cell development

WOODS HOLE, MA--A scientist at the Marine Biological Laboratory (MBL) has published the results of an EPA-funded clam embryo study that supports her hypothesis that, when combined, the pollutants bromoform, chloroform, and tetrachloroethylene--a chemical cocktail known as BCE--can act synergistically to alter a key regulator in nerve cell development. While scientists have previously studied the effects of these pollutants individually, this is the first time anyone has demonstrated that BCE's components can work together to adversely affect neuron growth in a model organism.

The study, which is reported in the January 2005 issue of Environmental Toxicology and Pharmacology, is the first step toward understanding how exposure to BCE might affect human nerve cell development--knowledge that may one day provide clues about such neurological mysteries as autism spectrum disorder or attention deficit hyperactivity disorder.

To test her hypothesis, MBL scientist Carol Reinisch and her colleagues treated developing surf clam embryos (Spisula solidissima) with different combinations of BCE and studied their effects on nerve cell growth. "On a cellular level, clam neurons are extremely useful in studying basic mechanisms of cell development," says Reinisch, an expert in PCB-induced neurotoxicity.

"Of the different combinations and strengths of BCE components tested, we found that all three together induce the greatest adverse response. Treating the embryos with the triple mixture resulted in increased production of a subunit of an enzyme called protein kinase A (PKA), which previous research suggests plays a role in neural development," says Reinisch. "Fluctuations in PKA may influence not only neuronal maturation but also how neuronal networks are constructed during development," she says. Alterations of this enzyme may affect neural development and neural connections by activating or inactivating other proteins.


'"/>

Contact: Pamela Clapp Hinkle
pclapp@mbl.edu
508-289-7276
Marine Biological Laboratory
13-Jan-2005


Page: 1 2 3

Related biology news :

1. UCLA scientists produce functioning neurons from human embryonic stem cells
2. Not all embryonic stem cell lines are created equal
3. Discredited Korean embryonic stem cells true origins revealed
4. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
5. Study provides new data about the laws governing embryo development in organisms
6. Germanys embryo protection law is killing embryos rather than protecting them
7. Time-lapse recordings reveal why IVF embryos are more likely to develop into twins
8. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
9. Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening
10. UCLA researchers reprogram normal tissue cells into embryonic stem cells
11. Reprogrammed fibroblasts identical to embryonic stem cells

Post Your Comments:
(Date:7/31/2014)... follow-up study (HPV-023; NCT00518336) shows the sustained ... papilloma virus (HPV) vaccine Cervarix. Women vaccinated ... for more than nine years, and vaccine ... This is the longest follow-up report for ... for the full paper. , ...
(Date:7/31/2014)... team of scientists from Spain, France, and the ... that is the oldest definitive member of the ... amber. The discovery and description were made possible ... synchrotron imaging technique, which allows the detailed study ... new species is described in the journal ...
(Date:7/31/2014)... Lincoln, Neb., July 31, 2014 -- Do people make ... their mothers raise them that way? Is it a ... of Nebraska-Lincoln and a colleague from Rice University say ... why some people lean left while others lean right. ... responses and deep-seated psychology are at the core of ...
Breaking Biology News(10 mins):Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3Scientists find growing consensus: Political attitudes derive from body and mind 2
(Date:8/1/2014)... Aug. 1, 2014 Cambrex Corporation (NYSE: ... 30, 2014. Highlights , Second ... in the same period last year. , Second quarter ... in the same period last year (see table at the ... guidance increased, excluding the impact of foreign currency, to between ...
(Date:7/31/2014)... Food and natural product manufacturers, ... food alternatives that offer variety, as well as, ... market has numerous players operating in the marketplace ... Technology (VFT). VFT is a science-driven functional ... all tested to produce stable, effective and repeatable ...
(Date:7/31/2014)... CHICAGO , July 31, 2014 Nearly ... 65 th Annual Meeting & Clinical Lab Expo ... The meeting featured never-before-seen breakthroughs in diagnostic research and ... treatment they need. As of Wednesday, July ... 2014 AACC Annual Meeting & Clinical Lab Expo, with ...
(Date:7/31/2014)... even the entire body to visualize long-range connections between ... a long-time dream of biologists. A study published by ... Cell has now made that dream a ... and human tissue biopsies transparent, while keeping the cellular ... way for a better understanding of brain-body interactions, more ...
Breaking Biology Technology:Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3See-through organs and bodies will accelerate biomedical discoveries 2
Cached News: