HOME >> BIOLOGY >> NEWS
Clock molecule's sensitivity to lithium sheds light on bipolar disorder

Researchers at the University of Pennsylvania School of Medicine discovered that a key receptor protein is a critical component of the internal molecular clock in mammals. What's more, this molecule called Rev-erb is sensitive to lithium and may help shed light on circadian rhythm disorders, including bipolar disorder. The findings, which also provide insight into clock-controlled aspects of metabolism, are reported in this week's issue of Science.

"We're interested in the internal control of metabolism because feeding behavior is on a daily cycle, and hormonal activities that regulate this are circadian," says senior author Mitch Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at Penn. "Many studies, including those here at Penn, suggest a relationship between the human circadian clock and metabolism. Proteins are the gears of the clock, and not much is known about what regulates protein levels within the cell."

Rev-erb was known to be a key component of the clock that exists in most cells of the body. Rev-erb inhibits clock genes called bmal and clock, but within a normal 24-hour circadian cycle the Rev-erb protein is destroyed within the cell, allowing bmal and other clock proteins to increase. Among other actions, these clock genes cause Rev-erb to increase, which again inhibits bmal and clock. "The time it takes for that to happen determines the length of the cycleroughly 24 hoursand keeps the clock going," explains Lazar.

Penn colleague and coauthor Peter Klein, MD, PhD, Assistant Professor of Medicine, discovered a few years ago that the drug lithium, used to treat biopolar illness, inhibits GSK3, an enzyme known to regulate circadian rhythm in several animal species. In the present study, the researchers showed that the destruction of Rev-erb, a receptor shown previously by Lazar and others to play a role in maintaining normal metabolism, is prevented by GSK3 in mouse and human cells. "It's like pullin
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
16-Feb-2006


Page: 1 2

Related biology news :

1. Clocking in and out of gene expression
2. Clock gene plays role in weight gain, study finds
3. Botulism bug says no to nitric oxide, provides key to molecules role in human cell signaling
4. Drought sensitivity shapes species distribution patterns in tropical forests
5. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
6. Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
7. Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
8. Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
9. New test predicts blood cancers sensitivity to experimental cancer drug
10. Genesearch Breast Lymph Node assay detects breast cancer metastases with greater sensitivity
11. Funnel in the eye: Signal focusing increases photosensitivity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/5/2019)... ... 05, 2019 , ... Catalent, the leading global provider of ... consumer health products, today announced it will present at the upcoming World Orphan ... – 14, 2019. , On Wednesday, Nov. 13 at 3:20 p.m., Philip Wills, ...
(Date:10/30/2019)... CUMBERLAND FORESIDE, Maine (PRWEB) , ... October 29, ... ... UC4 linearity and calibration verification kits, for SIEMENS ATELLICA® analyzers, Order Numbers 701sa ... GLU, K, MG, NA, PHOS, UA, UTP, and UUN. , Each VALIDATE® kit, ...
(Date:10/30/2019)... ... October 30, 2019 , ... ... and bioactivity that are encoded by the ordering of monomer residues into ... shift of the sidechain attachment to the backbone amide-nitrogen atoms. They are ...
Breaking Biology News(10 mins):
(Date:10/29/2019)... ... October 29, 2019 , ... Modality Solutions, a ... cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) Conference, November 11-12, ... The Biomanufacturing World Summit brings together pharmaceutical executives, cutting-edge technology providers, ...
(Date:10/22/2019)... ... October 22, 2019 , ... Enplug , a leading ... System into its digital signage platform. The collaboration brings one of the most ... users to leverage their existing digital signage networks to quickly disseminate critical safety ...
(Date:10/10/2019)... ... October 09, 2019 , ... The International ... Commissioner, FDA, as a newly-confirmed keynote speaker for the 2019 ISPE Annual ... USA. , Dr. Abernethy, a hematologist/oncologist and palliative medicine physician, is an internationally ...
(Date:10/8/2019)... ... 2019 , ... Erchonia Corporation, the global leader in the ... the U.S. Food and Drug Administration (FDA) has granted the company 510(k) market ... chronic neck and shoulder pain of musculoskeletal origin. , Erchonia continues to be ...
Breaking Biology Technology:
Cached News: