Cloned gene from sea animal may prove key in cancer drug d...( ngled out bryA a gene for a catalyst t...)

Cloned gene from sea animal may prove key in cancer drug development

ngled out bryA, a gene for a catalyst the authors propose is active in bryostatin biosynthesis.

The researchers say it appears that bryA may synthesize a portion of the pharmacologically active component of bryostatin and therefore may be useful in developing clinically useful bryostatin byproducts.

"The isolation of bryA represents a significant step forward inunderstanding bryostatin biosynthesis and eventually harnessing bry genes to produce bryostatins and derivatives inexpensively and in abundant quantities," the authors write in the paper, one of the first studies that describes such a cloning achievement from a marine symbiont organism.

Haygood and members of her laboratory are now moving the research forward by attempting to use bryA to extract laboratory-developed bryostatin compounds.

Most cancer drugs work by killing rapidly growing cells, in many cases interfering with the body's normal processes. Bryostatin seems to be effective by "flipping a switch" that controls how cells behave in the body. In the case of leukemia, for example, it seems to bring the cells "to their senses" and make them behave like normal blood cells.

In addition to Haygood, research coauthors include Mark Hildebrand, Laura Waggoner, Sebastian Sudek, Scott Allen and Christine Anderson of Scripps; and Haibin Liu and David H. Sherman of the Life Sciences Institute (Sherman was formerly at the University of Minnesota). Haygood is a member of Scripps's Marine Biology Research Division and Center for Marine Biotechnology and Biomedicine and the Rebecca and John Moores UCSD Cancer Center.

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Contact: Mario Aguilera or Cindy Clark
scrippsnews@ucsd.edu
858-534-3624
University of California - San Diego
10-Dec-2004

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