HOME >> BIOLOGY >> NEWS
Clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

In the human breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now scientists from the Icelandic Cancer Society and the Faculty of Medicine, University of Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties about these stem cells that could explain why they spawn malignancies.

These stem cells, Valgardur Sigurdsson remarked during the EuroSTELLS Conference in Venice, Italy (19-21 March), could become targets for cancer treatment, leading to new therapies that wipe out cancer at its source. The hope is that they might also become useful tools to test new drugs.

"People have long suspected there should be a stem cell population in the human breast gland," said Sigurdsson who is part of the ESF-funded team led by Thorarinn Gudjonsson. A 'virgin' breast, before pregnancy, is very different to a fully functioning, milk-producing breast. With lactation, the breast becomes fully differentiated, and once this stage is over, it involutes. This cycle of proliferation, differentiation and apoptosis also happens in every menstrual cycle and in a more dramatic form during pregnancy. "This caught our attention, and has driven our research," Sigurdsson pointed out.

Breast cancer almost always occurs in the luminal epithelial compartment, which is also where milk is produced. Perhaps it is not surprising then, that stem cells reside in this compartment. In 2002, Thorarinn Gudjonsson, successfully isolated cells from the human breast with stem cell properties.

Gudjonsson immortalised these cells and grew them in three dimensional matrix that mimics the real, living tissue. Biologists have long relied on 2-dimensional cell cultures as the basic tool of their trade. But there is a big difference between a f
'"/>

Contact: Jens Persson
jpersson@esf.org
33-38-876-2158
European Science Foundation
24-Apr-2006


Page: 1 2

Related biology news :

1. Clues to future evolution of HIV come from African green monkeys
2. Clues to gene expression in cystic fibrosis will guide research
3. Unraveling Alzheimers: Clues may be found visualizing plaques in human brain, mad cowtype diseases
4. Clues on cancer from a zebrafish model of melanoma
5. Clues to the puzzle of talking root cells
6. Clues to improving TB treatment
7. Newly created cancer stem cells could aid breast cancer research
8. New study suggests Concord grape juice may provide protection against breast cancer
9. U-M researchers identify gene involved in breast cancer
10. Additional mammogram readers improve breast cancer detection
11. Study finds Western-style meat-sweet diet increases risk of breast cancer in postmenopausal women

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clues breast cancer hidden inside stem cells

(Date:10/29/2014)... stem cell, those referred to as ,facultative, form part—together ... nothing that differentiates these cells from the others. However, ... the capacity to become stem cells again. This phenomenon ... that hosts cells that stimulate tissue growth, thus allowing ... a transplant. Knowledge of the underlying mechanism that ...
(Date:10/29/2014)... – Ghrelin is a hormone released by the stomach ... commonly viewed as a psychoactive substance that primarily affects ... food. , This knowledge, combined with findings from ... has the potential to stimulate alcohol craving. , Dr. ... and found that, as they had anticipated, alcohol craving ...
(Date:10/28/2014)... German . ... sufficient food when times are lean? By studying wild ... researchers of the Max Planck Institute for Evolutionary Anthropology ... great apes can acquire extra energy needed to maintain ... sleeping nests more en route to breakfast sites containing ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Ghrelin stimulates an appetite for drinking alcohol 2The early chimp gets the fig 2The early chimp gets the fig 3
(Date:10/27/2014)... Cary, North Carolina (PRWEB) October 27, 2014 ... was invited earlier this month to sit down with Bryan ... Spencer from RPG Solutions to discuss talent in the Research ... the topics that were highlighted at the roundtable ... in the Triangle, the significance of work/life balance and the ...
(Date:10/27/2014)... Oct. 27, 2014 Kalorama Information says that ... concern in the United States ... healthcare market researcher said the FDA,s Emergency Use Authorization (EUA) ... tests for the detection of the Ebola virus was ... Kalorama routinely assess the IVD industry and its biennial ...
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/26/2014)... The report "Data Center Networking Market [Ethernet ... Optimization Appliances]: Global Advancements, Worldwide Forecasts & Analysis ... market into various segments with an in-depth analysis ... the factors driving this market, various restraints and ... future roadmaps. , Browse 106 market data tables ...
Breaking Biology Technology:Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4
Cached News: