HOME >> BIOLOGY >> NEWS
Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment.

Aleksander Edelman and Isabelle Sermet-Gaudelus of Facult de Mdicine Necker in Paris led collaborators from several French institutions studying how the antibiotic gentamicin affected CF patients with a stop mutation. The team used a dual reporter gene assay first in vitro and then in CF patients. The study found that a small subgroup of patients with the Y122X mutation, found mainly in inhabitants of Reunion island, responded to gentamicin treatment.

Cystic fibrosis is caused by mutations in the gene that encodes the Cystic Fibrosis Transmemrane Conductance Regulator (CFTR) protein. Over 1500 mutations have been described since this genes discovery. Premature stop mutations, which includeY122X, are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients respiration.

Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trials outcome could be a first step to developing treatments effective for patients with CF and other diseases where premature stop codons play a role.


'"/>

Contact: Martyn Thomas
press@biomedcentral.com
44-020-763-19986
BioMed Central
28-Mar-2007


Page: 1

Related biology news :

1. Clues to future evolution of HIV come from African green monkeys
2. Unraveling Alzheimers: Clues may be found visualizing plaques in human brain, mad cowtype diseases
3. Clues to breast cancer hidden inside stem cells
4. Clues on cancer from a zebrafish model of melanoma
5. Clues to the puzzle of talking root cells
6. Clues to improving TB treatment
7. A low expression of MX2 gene exists in the white blood cells of narcoleptics
8. Gene expression pattern could lead to improved treatment of pediatric septic shock
9. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
10. Clocking in and out of gene expression
11. High cholesterol diets modify gene expression in atherosclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... (PRWEB) , ... August 19, 2020 , ... ... the premier conference and expo uniting life science, data science, informatics and IT ... sessions. , “In this period of uncertainty and change, Bio-IT takes the leadership ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently announced its newly ... health agencies of all sizes. With a focus on tracking symptoms and monitoring ... health care, Mosio helps public health departments automate communications and provide more personalized ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from ... and ProText™, making them the first Wharton’s jelly allografts to be assigned a Q ... company’s solutions are the first Wharton’s jelly allograft product to be recognized as a ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... firm, is making available for free its new white paper – Simulated ... simulation testing into today’s biologics licensing application (BLA). In response, Modality Solutions ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet ... , Known as MediVet Biologics since its formation in 2016, the ... new Ardent Animal Health will build on its base of innovative therapies for osteoarthritis ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet ... to three different materials for use with CRM, neurostimulation, vascular, and related devices. ... to meet specific design requirements, performance, and cost criteria; especially where solid wire ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: