Coarse particulate matter in air may harm hearts of asthma sufferers, UNC s...( articulate matter resulted in a three p...)

articulate matter resulted in a three percent decrease in a measure of heart rate variability, the variation of the beat-to-beat intervals of the heart. A healthy heart has wide heart rate variability, while decreased variability can indicate stress or cardiac disease.

Surprisingly, there was no relationship between coarse particulate matter and rescue medication use, asthma symptoms, lung function or airway inflammatory markers, Yeatts said. However, 10 of the 12 adult asthmatics in the study were taking anti-inflammatory controller medication for their disease, and nine of the 12 had mild disease. It is possible that anti-inflammatory treatment mitigated the effects in their airways, or that adults with asthma are less susceptible to the effects of coarse particulate matter.

Study participants consisted of 12 adults between the ages of 21 and 50 with persistent asthma. All lived within a 30-mile radius of the studys particulate matter monitor, located on the EPA Human Studies Facility at the Carolina campus. Each study participant took part in nine clinic visits: five the first week, and four spaced randomly over the subsequent six to 11 weeks. Data collection took place between September 2003 and July 2004. During the study, outdoor air levels of coarse particulate matter ranged between zero to 14.6 micrograms per cubic meter and did not exceed safety levels set by the EPA of 150 micrograms per cubic meter.

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Contact: Becky Oskin
becky_oskin@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
9-May-2007


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