HOME >> BIOLOGY >> NEWS
Coffee consumption linked to increased risk of heart attack for persons with certain gene variation

Individuals who have a genetic variation associated with slower caffeine metabolism appear to have an increased risk of non-fatal heart attack associated with higher amounts of coffee intake, according to a study in the March 8 issue of JAMA.

Studies examining the association between coffee consumption and risk of myocardial infarction (MI heart attack) have been inconclusive. Coffee is a major source of caffeine, which is the most widely consumed stimulant in the world and has been implicated in the development of cardiovascular diseases such as heart attack, according to background information in the article. However, coffee contains a number of other chemicals that have variable effects on the cardiovascular system. It is not clear whether caffeine alone affects the risk of heart attack or whether other chemicals found in coffee may be responsible. Caffeine is metabolized primarily by the enzyme cytochrome P450 1A2 (CYP1A2) in the liver. Variations of the gene for this enzyme can slow or quicken caffeine metabolism. Carriers of the gene variant CYP1A2*1F allele are "slow" caffeine metabolizers, while individuals with the gene variant CYP1A2*1A allele are "rapid" caffeine metabolizers.

Ahmed El-Sohemy, Ph.D., of the University of Toronto, and colleagues conducted a study to determine whether gene variations of CYP1A2 modifies the association between consumption of caffeinated coffee and risk of nonfatal heart attack. The study included 2,014 case patients with a first acute nonfatal heart attack and 2,014 controls, living in Costa Rica between 1994 and 2004. The genotypes of the participants were determined. A food frequency questionnaire was used to assess the intake of caffeinated coffee.

Fifty-five percent of cases (n = 1,114) and 54 percent of controls (n = 1,082) were carriers of the slow *1F allele. For carriers of the slow *1F allele, those who drank 2 to 3 cups of coffee a day had a 36 percent increased odds of heart attack; thos
'"/>

Contact: Elizabeth Monier-Williams
416-978-5948
JAMA and Archives Journals
7-Mar-2006


Page: 1 2

Related biology news :

1. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
2. Coffee, black, decaf and a little llama on the side
3. Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
4. Apple consumption during pregnancy reduces risk for childhood wheezing and asthma
5. Link between beef consumption during pregnancy and reduced sperm quality in sons
6. Maternal seafood consumption benefits childrens development
7. Exercise, aspirin consumption and childbirth may alter cancer risk
8. Poultry consumption, handling are risk factors for antibiotic resistance in humans
9. Study shows fruit and vegetable juice consumption may reduce risk of Alzheimers disease
10. Timing of food consumption activates genes in specific brain area, researchers find
11. Gazelles shrink liver and heart to reduce oxygen consumption during drought

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/28/2016)... , Nov. 28, 2016 ... a rate of 16.79%" The biometric system market ... grow further in the near future. The biometric system ... billion in 2022, at a CAGR of 16.79% between ... system, integration of biometric technology in smartphones, rising use ...
(Date:11/21/2016)... 2016   Neurotechnology , a provider of ... announced that the MegaMatcher On Card fingerprint matching ... the NIST Minutiae Interoperability Exchange (MINEX) III ... steps of the evaluation protocol. ... of fingerprint templates used to establish compliance of ...
(Date:11/16/2016)... SANTA CLARA, Calif. , Nov. 16, 2016 /PRNewswire/ ... company enhancing user experience and security for consumer ... provider for the financial and retail industry, today ... more secure and convenient way to authenticate users ... now uses Sensory,s TrulySecure™ software which ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... York, NY (PRWEB) , ... December 01, 2016 , ... ... event is expanding to three days and will take place on February 1-3, 2017 ... (GSK) and Dr James Gulley (NCI), the program provides a unique 360-degree approach, which ...
(Date:12/2/2016)... , Dec. 1, 2016   SurePure, Inc. ... announced today that the Company has concluded an agreement ... right for a 90-day period to acquire units of ... of approximately USD 3.7 million.  Concurrently ... with Tamarack under which Tamarack will seek regulatory approvals ...
(Date:11/30/2016)... 2016 The global Pyrogen Testing ... a dominant share in the overall market. The leading ... and Merck KGaA, held a lion,s share of 51% ... observes that these companies are expected to retain their ... are do not require rabbit pyrogen testing along with ...
(Date:11/30/2016)...  Tempus, a technology company focused on supporting ... Cancer Center have partnered to better determine which ... treatment based on next generation genomic and transcriptomic ... research collaboration, Tempus will provide sequencing and analysis ... to Penn. Utilizing next-generation sequencing, machine learning and ...
Breaking Biology Technology:
Cached News: