HOME >> BIOLOGY >> NEWS
Coffee consumption linked to increased risk of heart attack for persons with certain gene variation

Individuals who have a genetic variation associated with slower caffeine metabolism appear to have an increased risk of non-fatal heart attack associated with higher amounts of coffee intake, according to a study in the March 8 issue of JAMA.

Studies examining the association between coffee consumption and risk of myocardial infarction (MI heart attack) have been inconclusive. Coffee is a major source of caffeine, which is the most widely consumed stimulant in the world and has been implicated in the development of cardiovascular diseases such as heart attack, according to background information in the article. However, coffee contains a number of other chemicals that have variable effects on the cardiovascular system. It is not clear whether caffeine alone affects the risk of heart attack or whether other chemicals found in coffee may be responsible. Caffeine is metabolized primarily by the enzyme cytochrome P450 1A2 (CYP1A2) in the liver. Variations of the gene for this enzyme can slow or quicken caffeine metabolism. Carriers of the gene variant CYP1A2*1F allele are "slow" caffeine metabolizers, while individuals with the gene variant CYP1A2*1A allele are "rapid" caffeine metabolizers.

Ahmed El-Sohemy, Ph.D., of the University of Toronto, and colleagues conducted a study to determine whether gene variations of CYP1A2 modifies the association between consumption of caffeinated coffee and risk of nonfatal heart attack. The study included 2,014 case patients with a first acute nonfatal heart attack and 2,014 controls, living in Costa Rica between 1994 and 2004. The genotypes of the participants were determined. A food frequency questionnaire was used to assess the intake of caffeinated coffee.

Fifty-five percent of cases (n = 1,114) and 54 percent of controls (n = 1,082) were carriers of the slow *1F allele. For carriers of the slow *1F allele, those who drank 2 to 3 cups of coffee a day had a 36 percent increased odds of heart attack; thos
'"/>

Contact: Elizabeth Monier-Williams
416-978-5948
JAMA and Archives Journals
7-Mar-2006


Page: 1 2

Related biology news :

1. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
2. Coffee, black, decaf and a little llama on the side
3. Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
4. Apple consumption during pregnancy reduces risk for childhood wheezing and asthma
5. Link between beef consumption during pregnancy and reduced sperm quality in sons
6. Maternal seafood consumption benefits childrens development
7. Exercise, aspirin consumption and childbirth may alter cancer risk
8. Poultry consumption, handling are risk factors for antibiotic resistance in humans
9. Study shows fruit and vegetable juice consumption may reduce risk of Alzheimers disease
10. Timing of food consumption activates genes in specific brain area, researchers find
11. Gazelles shrink liver and heart to reduce oxygen consumption during drought

Post Your Comments:
(Date:7/29/2014)... new study from UC San Francisco is the first ... accumulate overtime and accelerate cellular aging, these negative effects ... and sleeping well. , "The study participants who ... shortening than the ones who didn,t maintain healthy lifestyles, ... lead author Eli Puterman, PhD, assistant professor in the ...
(Date:7/28/2014)... the South Pole in 1911, but new research shows ... , Using data from 16 ice cores collected from ... South Pole, a group led by Joe McConnell of ... the most accurate and precise reconstruction to date of ... described in an article published today in the online ...
(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
(Date:7/29/2014)... 2014 According to the new ... Analytics (Image Analysis Software), Delivery Modes (Web Based/Cloud Based) ... Trends to 2018", published by MarketsandMarkets, analyzes and studies ... as North America , ... the Rest of the World (RoW). Browse ...
(Date:7/29/2014)... A new report by Allied ... and geography) - Size, Share, Global Trends, Company Profiles, ... 2013 - 2020", suggests that the global surgical equipment ... registering a CAGR of 11.1% from 2014 to 2020. ... electro surgical devices in operative procedures by providing highly ...
(Date:7/29/2014)... TransVac Solutions, the trusted leader in automated waste, ... hospitals, will be exhibiting at booth #209 at the ... Technical Exhibition Aug. 3-6 in Chicago, Ill. ... cleaner, reducing infection risk and saving millions in labor ... Staff will be available at booth #209 to explain ...
(Date:7/29/2014)... Genera Energy Inc. , a ... supply chain advancements, has announced the deployment of ... and Supply ASSURE™. Both systems were developed ... at consolidating and simplifying the entire process, managing ... feedstock end users. , “Through the Energy Grange ...
Breaking Biology Technology:Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4
Cached News: