HOME >> BIOLOGY >> NEWS
Collaborative Cross to provide powerful resource for mouse model researchers worldwide

OAK RIDGE, Tenn., Sept. 22, 2005 -- A thousand new strains of mice being bred at Oak Ridge National Laboratory as part of an international effort will provide researchers with a powerful resource for studying human disease.

The project, dubbed the Collaborative Cross, has officially begun with a $1.25 million grant over five years from the Ellison Medical Foundation. When completed in about seven years, researchers worldwide will be able to fully exploit the genetic power of the mouse. Each of the estimated 1,000 strains derived from the carefully selected original eight breeds represents a resource that can be used repeatedly to accumulate data.

"Ultimately, this effort will allow us to do a much better job of modeling human populations and diseases because we will have 1,000 lines of mice that carry the kinds of genetic diversity representative of people," said Dabney Johnson, a genetics researcher in ORNL's Life Sciences Division. Johnson headed a team that wrote the proposal to the Ellison Medical Foundation.

At the heart of the project is the new $14 million Laboratory for Comparative Functional Genomics at the Department of Energy's ORNL. The pathogen-free 36,000-square-foot facility completed in 2004 boasts accommodations for 80,000 mice, cryogenic storage and other state-of-the-art features. It is at this designated DOE user facility that the breeding of the eight strains taken from around the world will be performed to initiate up to 1,500 strains of mice. Of those, researchers expect about 1,000 strains to be viable as inbreeding proceeds.

Without DOE's stewardship of the new mouse facility, the project would not be possible, said Johnson, who noted that DOE is contributing not only the space within the facility but also the technical capabilities that will allow the work to be performed.

The project, which will occupy about half of the new ORNL mouse house's capacity, is a perfect fit for ORNL, according to Johnson.
'"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
22-Sep-2005


Page: 1 2 3

Related biology news :

1. Collaborative study successfully applies neutrons to study hydrogen transfer in biological systems
2. A Cross-Disciplinary Look at Scientific Truth: Whats the Law to Do?
3. Crossing the Valley of Death: Moving science into practice and policy
4. Stem Cells: Saving Lives or Crossing Lines?
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Female gender provides an advantage in renal diseases
7. Forecasting system provides flood warnings to vulnerable residents of Bangladesh
8. Discovery of new protein could provide new understanding of male fertility
9. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
10. Genomics study provides insight into the evolution of unique human traits
11. Expert to provide update after worst tomato virus hits California

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case ... Denmark detail how a patient who developed lymphedema after being treated for breast cancer ... could change the paradigm for dealing with this debilitating, frequent side effect of cancer ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
Breaking Biology Technology:
Cached News: