HOME >> BIOLOGY >> NEWS
Collaborative study successfully applies neutrons to study hydrogen transfer in biological systems

An innovative collaboration among scientists at Los Alamos National Laboratory, Fox Chase Cancer Center and the University of Tennessee has successfully applied neutron diffraction to create a three-dimensional map of the structure of the enzyme D-xylose isomerase. It is a model system for understanding other proteins involved in biological processes.

The first to locate the enzyme's active hydrogen atoms, the new research will be published on-line the week of May 15-19 in the early edition of Proceedings of the National Academy of Sciences as well as in the journal's June issue. Hydrogen atoms are the workhorses of the enzyme, carrying out the chemical reactions it facilitates--such as the conversion of glucose to fructose to produce the high-fructose corn syrup widely used to sweeten sodas and other commercial foods.

Finding the hydrogen atoms reveals how water (H2O) molecules are bound in a protein. The way water interacts influences the protein's function.

Work in the Fox Chase laboratory of Jenny P. Glusker, D.Phil., first revealed the structure of D-xylose isomerase in 1984 using X-ray crystallography.

"However, this technique does a poor job of locating hydrogen atoms, which make up about half of all atoms in a protein," explained Amy K. Katz, a Fox Chase visiting scientist from the University of Tennessee at Knoxville and a lead author of the new report along with Gerard J. Bunick, Ph.D., of the University of Tennessee.

"Now, using the world's only spallation neutron source equipped for protein diffraction studies, based at Los Alamos National Laboratory, it has been possible to locate the hydrogen atoms at active sites in crystals of D-xylose isomerase," Katz said. "This research demonstrates the potential for locating and understanding hydrogen-atom transfer processes in large biological systems, which could lead to improved and better-targeted medicines."

X-Rays Versus Neutrons

The longest
'"/>

Contact: Karen Mallet
Karen.Mallet@fccc.edu
215-728-2700
Fox Chase Cancer Center
15-May-2006


Page: 1 2

Related biology news :

1. Collaborative Cross to provide powerful resource for mouse model researchers worldwide
2. New study warns limited carbon market puts 20 percent of tropical forest at risk
3. Clones on task serve greater good, evolutionary study shows
4. Pollution causes 40 percent of deaths worldwide, study finds
5. A study by the MUHC and McGill University opens a new door to understanding cancer
6. New study suggests Concord grape juice may provide protection against breast cancer
7. Preclinical study links gene to brain aneurysm formation
8. In limiting life span, study finds booming bacteria innocent
9. Multicenter study nets new lung tumor-suppressor gene
10. MIT study: Maturity brings richer memories
11. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ... , ... PureWay, a healthcare-focused provider of sharps disposal, biohazard ... of sales and business development efforts, effective immediately. Mr. Kennedy will report directly ... Johnson & Johnson Medical, Globus Medical, WRP Asia Pacific, and Stryker, all where ...
(Date:1/7/2019)... ... January 07, 2019 , ... Concerto HealthAI, a ... precision health in oncology and other key therapeutic areas, and its Chief Executive ... entrepreneurs and executives spanning the entire healthcare landscape, on January 8, 2019, at ...
(Date:1/5/2019)... ... 04, 2019 , ... Join Bill Fox, Chief Strategy Officer, ... from MarkLogic – for a live webinar on Wednesday, January 16, ... using real world data for pharmacovigilance, and the implications of current inefficient data ...
Breaking Biology News(10 mins):
(Date:1/11/2019)... , ... January 11, 2019 , ... Drawing on over ... Tuesday, January 22, 2019 at 2:30pm EST will explore some of the key lessons ... of using one vendor vs. using multiple vendors, and find out how to ensure ...
(Date:1/8/2019)... ... January 07, 2019 , ... ... into Noninvasix. This represents the second investment AngelMD has made into Noninvasix in ... Noninvasix is developing a patient monitor to directly, accurately, and noninvasively measure brain ...
(Date:1/4/2019)... , ... January 01, 2019 , ... ... Microbiome Conference at the World Economic Forum Annual Meeting January 22-25, 2019 held ... is invitation-only. , The World Economic Forum Annual Meeting brings together leaders of ...
(Date:12/19/2018)... ... December 19, 2018 , ... R3 Stem Cell is ... Training Course in Las Vegas. Training includes facial rejuvenation, hair restoration and erectile ... nationwide for aesthetics, having the training from expert, Board Certified providers is critical ...
Breaking Biology Technology:
Cached News: