HOME >> BIOLOGY >> NEWS
Columbia University researchers create mouse model that develops a human-like lymphoma

Researchers at Columbia University Medical Center have created the first mouse model that develops a lymphoma the same way that humans do. This advancement has the potential to significantly speed the development of new, improved therapies for diffuse large B cell lymphoma (DLBCL), the most common type of human B cell lymphoma. Human B cell lymphomas cause 85 percent of non-Hodgkin's lymphomas, the sixth leading cause of cancer deaths in the United States.

The findings also confirm that a mutation in BCL6, the gene most frequently altered in this type of lymphoma, is the first step in its development, though other subsequent mutations also occur. In the study, mice with a mutant form of this gene spontaneously developed this lymphoma.

Cancer researchers have long been hindered by the lack of animal models to recreate both the genetics and biology of DLBCL. They had no way to test, with reliable accuracy, how an investigational therapy would work in humans with this disease. Also, this lack of animal models has slowed understanding of the BCL6 gene and its precise role in tumor development.

Published in the May 2005 issue of Cancer Cell, the study was led by Riccardo Dalla-Favera, M.D., one of the world's leading cancer geneticists and lymphoma researchers. Dr. Dalla-Favera is director of the Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University Medical Center and NewYork-Presbyterian/Columbia. The HICCC is one of only three NIH-designated Comprehensive Cancer Centers in New York State. He is also director of the Institute for Cancer Genetics at Columbia University Medical center.

Dr. Dalla-Favera and his research team genetically engineered mice to produce a mutant BCL6 gene, showing the specific role of this gene in its pathogenesis and displaying most of the critical features of the corresponding human tumor. These findings expand on Dr. Dalla-Favera's identification of the BCL6 gene in 1994.

"We
'"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
16-May-2005


Page: 1 2

Related biology news :

1. Columbia University Medical Center awarded $3 million to drive Alzheimers genetics research
2. Columbia scientists determine 3-dimensional structure of cells fuel gauge
3. Columbia University licenses next-generation DNA sequencing technology
4. New bird discovered on unexplored Columbian mountain
5. Columbia University Medical Center receives major new NIH Clinical Science investment funds
6. Columbia University awards 2006 Horwitz Prize to biologist who explained gene transcription
7. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
8. Contaminants linked to sturgeon decline in Columbia river
9. Columbia University Medical Center researchers discover potential mechanism for tumor growth
10. UF, Columbia scientists closer to new cancer detection method
11. Columbia University awards 2005 Horwitz Prize to Israeli structural biologist

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/2/2018)... ... October 02, 2018 , ... The Federal Identity ... at Tampa Convention Center. The Palo Alto-based face recognition company, Camvi Technologies Inc., ... 27th. Other speakers included U.S. Federal executives from Department of Defense (DoD) and ...
(Date:10/1/2018)... ... 2018 , ... Paragon Biosciences CEO Jeff Aronin was recently recognized by Insights ... bringing life-altering drugs to patients in need. Jeff’s vision has led Paragon to the top ... teams now at Paragon and its portfolio companies. , From his inspiration as ...
(Date:9/29/2018)... ... September 29, 2018 , ... ReimbursementIQ is offering ... The in-person briefings are expected to transform Medical Affairs, Market Access, and Marketing ... U.S. healthcare market—especially to individuals, employers, and other healthcare purchasers. , ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... ... The American Medical Informatics Association (AMIA) is proud to announce the 2018 ... AMIA 2018 Annual Symposium , taking place Nov. 3 – 7, in San ... than 700 submissions. The AMIA Signature Awards program provides an opportunity for AMIA members ...
(Date:10/11/2018)... ... October 10, 2018 , ... Boston Biotech Conferences, ... of Wendy Nelson, PhD, as its new CEO. , Dr. Nelson has over ... biotech industry. Most recently, Dr. Nelson was VP of Business Development, Marketing ...
(Date:10/11/2018)... ... October 11, 2018 , ... Avery Products Corp., the world’s ... with HP, the global leader in printing, has obtained the British Standard 5609 ... HP PageWide Printers. , The award-winning Avery UltraDuty GHS Chemical Labels, combined with ...
(Date:10/5/2018)... ... October 04, 2018 , ... Karius , a ... announced today at IDWeek™ 2018 the positive results of a study demonstrating that ... accurately identified causative pathogens in patients with infective endocarditis even when blood cultures ...
Breaking Biology Technology:
Cached News: