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Common fungicide causes long-term changes in mating behavior

AUSTIN, TexasFemale rats avoid males whose great-grandfathers were exposed to a common fruit crop fungicide, preferring instead males whose ancestors were uncontaminated, researchers from The University of Texas at Austin have discovered.

Their research shows that environmental contamination could affect the evolution of wildlife through changes in mating behavior.

Drs. David Crews and Andrea Gore examined mate preference in male and female rats whose great-grandparents were exposed to the fungicide vinclozolin, which causes early onset of cancer and kidney disease in males.

They found that female rats could tell the difference between male descendants of rats that had or had not been exposed to vinclozolin.

The females strongly preferred to associate with males descended from unexposed rats.

Their research will be published the week of March 26-30 in the online Early Edition of the Proceedings of the National Academy of Sciences.

Even across generations, your attractiveness as a mate is decreased if your great-grandfather has been exposed to environmental chemicals, said Gore, professor of pharmacology and toxicology in the College of Pharmacy. That will have an impact on your ability to reproduce and could take you out of the gene pool.

Vinclozolin causes changes in the male rats germline cells (for example, sperm). The fungicide does not directly alter DNA, but instead causes changes in elements that regulate genes. This is known as an epigenetic change.

In the rats studied by Crews and Gore, the early onset of disease caused by initial exposure to vinclozolin was passed down generation to generation through the germline of the males.

For the first time, Crews and Gore show the inherited epigenetic change can affect behavior.

The important thing about this research is that it takes epigenetics to the brain, said Crews, the Ashbel Smith Professor of Integra
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Contact: David Crews
crews@mail.utexas.edu
512-471-1113
University of Texas at Austin
26-Mar-2007


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