HOME >> BIOLOGY >> NEWS
Common mechanisms for viral DNA replication

How DNA replicates is a critical question for understanding life. DNA replication remains difficult to investigate in eukaryotes,where it occurs within the confines of the double-membrane nucleus. However, the process is far easier to study in the much simpler virus. In simian virus 40 (SV40), the large T-antigen protein (T-ag) is responsible for recognizing DNA sequences required to start replication, called the origin of replication. SV40 T-ag can also cause DNA to melt or unwind. In a new study published online in the open access journal PLoS Biology, Gretchen Meinke, Andrew Bohm, and colleagues report the crystal structure of the DNA-binding domain of SV40 T-ag on a DNA fragment derived from the viral origin of replication.

The structure shows that although T-ag and its functionally analogous protein, papilloma virus E1, share no detectable sequence homology in this region, the two domains bind the DNA in similar ways. In both cases, DNA binding is thought to initiate assembly of a complex of the full-length proteins on DNA. Interestingly, SV40 T-ag DNA-binding domains do not interact with one another when bound to DNA. In addition to describing the molecular details of the DNAprotein interactions and the alterations in protein structure induced by DNA binding, we present a model describing the subsequent assembly events.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
22-Jan-2007


Page: 1

Related biology news :

1. Common environmental chemicals in diet affect fetal ovarian development
2. Common cancer gene sends death order to tiny killer
3. Common treatment for methamphetamine overdose may damage brain cells
4. Common genetic variation is linked to substantial risk for heart attack
5. Common fungicide causes long-term changes in mating behavior
6. DNA ends: Common tool, different job
7. Common gene version optimizes thinking -- but with a possible downside
8. Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
9. Common cause of heart disease, diabetes may be treatable with malaria drug
10. Commonplace sugar compound silences seizures
11. Common garden plant threatened by climate change

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 29, 2019 , ... Advancements with Ted Danson ... an upcoming episode, which is scheduled to broadcast 1Q/2020. Check local listings for ... cost-effective robotic surgical solutions for the treatment of patients suffering from spinal disorders. ...
(Date:8/27/2019)... ... ... Shoreline Biome , a microbiome research company that develops tools for ... CEO and Karen Woodward as its VP of Business Development. , These two ... and expand the company’s sales worldwide. , Prior to joining Shoreline Biome, Bill McKenzie ...
(Date:8/27/2019)... Fla. (PRWEB) , ... August 27, 2019 , ... ... in life science and drug development. This episode is scheduled to broadcast 4Q/2019. ... explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show will ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 16, 2019 , ... When a lot of researchers think ... for the complete 3D characterization of tissues through the use of confocal and light ... image analysis and advanced cell culture focused contract research organization and today offers ...
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... ... September 10, 2019 , ... Catalent, the ... biologics, gene therapies, and consumer health products, today announced that Alex Haig, Senior ... Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, on Sept. 18-19, 2019. , On ...
(Date:9/8/2019)... ... September 05, 2019 , ... Spartan Bioscience, the leader in ... for Shopify, has been named Chief Financial Officer. , Spartan has also ... strategic advisors. Additionally, Spartan has hired Steve Edgett as Executive Vice President to ...
Breaking Biology Technology:
Cached News: