HOME >> BIOLOGY >> NEWS
Commonplace sugar compound silences seizures

MADISON - Though in clinical use for decades, a small, sweet-tasting compound is revealing a startling new face as a potential cure for epilepsy.

2-deoxy-glucose, or 2DG, has long been used in radio labeling, medical scanning and cancer imaging studies in humans. But now, researchers at the University of Wisconsin-Madison have found the substance also blocks the onset of epileptic seizures in laboratory rats.

Reported in the journal Nature Neuroscience, the findings have potentially huge implications for up to half of all epileptic patients who currently have no access to treatment, says senior author Avtar Roopra, a UW-Madison assistant professor of neurology.

"We pumped the rats full [of 2DG] and still saw no side effects," says Roopra, who estimates that the compound may be available for human use within five years. "I see 2DG as an epilepsy management treatment much like insulin is used to treat diabetes."

"All the available epilepsy treatments have focused on suppressing seizures," says co-author and renowned epilepsy expert Tom Sutula, a UW-Madison professor of neurology. "There has been hope that [new drugs] will not only suppress seizures, but modify their consequences. [2DG] appears to be a novel treatment that offers great promise to achieve that vision."

About 1 percent of the world's population suffers from epilepsy, a neurological condition that makes people susceptible to seizures. Scientists believe that seizures, of which there are many kinds, occur due to sudden changes in how brain cells send electrical signals to each other. In about 30 to 50 percent of epilepsy patients, available treatments - including the removal of parts of the brain's temporal lobe - are largely ineffective.

2DG is essentially a more palatable version of the "ketogenic," or sugar-free, diets that some researchers have long recommended to epilepsy patients. Indeed, the notion of a sugar-free diet actually stretches ba
'"/>

Contact: Avtar Roopra
roopra@neurology.wisc.edu
608-265-9072
University of Wisconsin-Madison
15-Oct-2006


Page: 1 2 3

Related biology news :

1. Nicotine rush hinges on sugar in neurons
2. White blood cells are picky about sugar
3. Study shows cane sugar, corn sweeteners have similar effects on appetite
4. A spoonful of sugar helps your waistline go down
5. Novel sugar-to-hydrogen technology promises transportation fuel independence
6. New role for sugars: Research shows connections between sugar modifications in cells and cancer
7. Blood sugars manufacture limited by building blocks supply
8. Juiced-up battery fueled by sugar could power small portable electronics
9. Iowa State researchers improve soy processing by boosting protein and sugar yields
10. New diabetes research: Half of Americans have gene that affects how body burns sugar
11. From managing sugar to managing healing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... July 16, 2020 , ... A study has ... Invictus Medical Neoasis™ active noise control device to attenuate typical noises in a ... device attenuated the alarm sounds from patient monitors, ventilators and other bedside devices ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/4/2020)... ... 2020 , ... Aesthetics Biomedical (ABM), a leading aesthetics product ... only the products and treatments developed, but also the dedicated team behind the ... brands built by ABM have received several honors already for 2020, each of ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions Life ... webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , The ... medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) and ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra ... life sciences and food industries, is pleased to announce that Charles Galea has ... Business Development. , Charles is an accomplished and results-driven sales executive with over ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license to ... move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
Breaking Biology Technology:
Cached News: