HOME >> BIOLOGY >> NEWS
Commonplace sugar compound silences seizures

ck thousands of years to Biblical times, when healers sometimes prescribed starvation as a potent way to fend off seizures.

UW-Madison researchers first began to investigate the role of sugar in controlling seizures after early experiments showed that children on sugar-free diets can rapidly experience seizures when they consume even a small dose of carbohydrates, such as a cookie or a little piece of bread.

But ketogenic regimens can be a miserable experience. "The kids can't eat any sugar at all. Imagine no bread or Christmas cake," says Roopra. But 2DG would work as an effective substitute because it enters cells and clogs up certain cellular enzymes. As a result, the body can't use its own glucose.

Though ketogenic diets seem to work in many epilepsy patients in whom existing treatments have been unsuccessful, scientists have struggled to understand the exact cellular connection between no sugar and no seizures. The UW-Madison work for the first time clears up some of that mystery.

Roopra has long explored how certain proteins known as "transcription factors" turn neuronal genes on or off. He has been particularly intrigued by one transcription factor known as NRSF, which is thought to control up to 1,800 genes in the brain, including many that are implicated in epilepsy. Like an electrical motherboard, NRSF ensures that neuronal genes switch "on" in the body's neurons, while remaining switched "off" in other regions where they normally play no role.

Roopra found that NRSF binds to another protein called CTBP. The finding "immediately raised alarm bells," Roopra says, because CTBP also binds to a free-floating molecule - NADH - that emerges when sugars break down in cells. To his surprise, Roopra found that CTBP binds to either NRSF or NADH. In other words, a cell with a lot of glucose generates a lot of NADH, so CTBP is more likely to bind with the sugar byproduct than NRSF. But without CTBP, NRSF most likely de
'"/>

Contact: Avtar Roopra
roopra@neurology.wisc.edu
608-265-9072
University of Wisconsin-Madison
15-Oct-2006


Page: 1 2 3

Related biology news :

1. Nicotine rush hinges on sugar in neurons
2. White blood cells are picky about sugar
3. Study shows cane sugar, corn sweeteners have similar effects on appetite
4. A spoonful of sugar helps your waistline go down
5. Novel sugar-to-hydrogen technology promises transportation fuel independence
6. New role for sugars: Research shows connections between sugar modifications in cells and cancer
7. Blood sugars manufacture limited by building blocks supply
8. Juiced-up battery fueled by sugar could power small portable electronics
9. Iowa State researchers improve soy processing by boosting protein and sugar yields
10. New diabetes research: Half of Americans have gene that affects how body burns sugar
11. From managing sugar to managing healing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2019)... (PRWEB) , ... October 04, 2019 , ... ... 2019 will be held November 10 at the Grand Elysée Hamburg Rothenbaumchaussee in ... to Europe again this November,” said Miao Guo, Vice President of Operations and ...
(Date:10/3/2019)... , ... October 02, 2019 , ... ... source of financing and ongoing support for Connecticut’s innovative, growing companies, today announced ... protection company for mobile payments and winner of the 2018 VentureClash ...
(Date:9/30/2019)... ... September 30, 2019 , ... ... supplier of innovative human mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announced ... to “Ready-to-Print” (RTP) cellular product formats (patent number AU 2015259373). This new ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia ... therapy technology (“3LT®”), today announces that the U.S. Food and Drug Administration (FDA) ... laser for the temporary relief of chronic neck and shoulder pain of musculoskeletal ...
(Date:10/3/2019)... Ariz. (PRWEB) , ... October 01, 2019 , ... ... your brain relax and reset itself, announced the midway point of its randomized ... objective of the study is to measure the efficacy of a non-invasive technology ...
(Date:10/3/2019)... , ... October 02, 2019 , ... ... life sciences leadership firm that is enabling clinical program outsourcing success by cultivating ... by award-winning pharma and biotech veteran executive Brenda Reese, phaseUP™ brings clients deep, ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging ... Accelerator run by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm ... in NHS by providing support to develop and deploy solutions to the most pressing ...
Breaking Biology Technology:
Cached News: