HOME >> BIOLOGY >> NEWS
Comparative chromosome study finds breakage trends, cancer ties

CHAMPAIGN, Ill. -- Breakages in chromosomes in mammalian evolution have occurred at preferred rather than random sites as long thought, and many of the sites are involved in human cancers, an international team of 25 scientists has discovered.

The researchers, reporting in the July 22 issue of the journal Science, also found that chromosomal evolution has accelerated, based on the rate of breakages and reorganization, since the extinction of dinosaurs 65 million years ago.

In a study led by Harris A. Lewin of the University of Illinois at Urbana-Champaign and William J. Murphy of Texas A&M University, the organization of chromosomes of humans, mice, rats, cows, pigs, dogs, cats and horses was compared at high resolution.

"This study has revealed many hidden secrets on the nature and timing of genome evolution in mammals, and it demonstrates how the study of basic evolutionary processes can lead to new insights into the origin of human diseases," said Lewin, the director of the Institute for Genomic Biology at Illinois and a professor of animal sciences.

The multi-species comparison was aided by a computer visualization tool -- the "Evolution Highway" -- developed by collaborators in the Automated Learning Group at the National Center for Supercomputing Applications at Illinois. Other lead participants were from the University of California at San Diego and the Genome Institute of Singapore.

The acceleration of evolution since dinosaurs disappeared surprised the researchers, who studied a computer-generated reconstruction of genomes of long extinct mammals, including the ancestor of the majority of living placental mammals of 94 million years ago.

"Based on our findings of the mammalian rate speed-up, we postulate that early mammals, with conservative body plans, retained fairly conserved genomes, as evidenced in the striking similarities in the reconstructed ancestral genomes," Murphy said.

"The widespread orig
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
21-Jul-2005


Page: 1 2 3 4

Related biology news :

1. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
2. Comparative Environmental Politics
3. APS Comparative-Evolutionary Physiology Conference showcases relevance of animal diversity
4. NYUs Center for Comparative Functional Genomics helps to unravel the function of microRNAS
5. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
6. Double identities lie behind chromosome disorders
7. St. Jude study yields secrets of chromosome movement
8. Physicist cracks womens random but always lucky choice of X chromosome
9. Researchers shed light on shrinking of chromosomes
10. Researchers attach genes to minichromosomes in maize
11. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 03, 2020 , ... Litmus Health , the research-ready ... of the company’s security practices has been completed. The assessment deemed Litmus infrastructure ... evaluation reviewed Litmus’ processes and systems, assessing them to see whether they adhere ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, ... magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking of ... as well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
(Date:8/21/2020)... ... August 19, 2020 , ... The 19th ... life science, data science, informatics and IT leaders goes VIRTUAL and announces its ... uncertainty and change, Bio-IT takes the leadership role of keeping our life science ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 ... ... biopharmaceutical cold chain validation engineering firm, is making available for free its ... need to incorporate concurrent transport simulation testing into today’s biologics licensing application ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, ... President and CEO has been named one of the 100 most inspiring individuals ... PharmaVoice 100 honorees are selected based on how they have inspired their colleagues ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. (Nasdaq: ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene ... strategic partnership whereby Catalent will provide support for the development, manufacturing, and clinical ...
Breaking Biology Technology:
Cached News: