HOME >> BIOLOGY >> NEWS
Complex channels

The messages passed in a neuronal network can target something like 100 billion nerve cells in the brain alone. These, in turn communicate with millions of other cells and organs in the body. How, then, do whole cascades of events trigger responses that are highly specific, quick and precisely timed? A team at the Weizmann Institute of Science has now shed light on this mysterious mechanism. Their discovery could have important implications for the future development of drugs for epilepsy and other nervous system diseases. These findings were recently published in the journal Neuron.

The secret is in the control over electrical signals generated by cells. These signals depend on ion channels membrane proteins found in excitable cells, such as nerve cells that allow them to generate electrical signals, depending on whether the channels are opened or closed. Prof. Eitan Reuveny, together with Ph.D. students Inbal Riven and Shachar Iwanir of the Weizmann Institutes Biological Chemistry Department, studied channels that work on potassium ions and are coupled to a protein called the G protein, which when activated, causes the channel to open. Opening the channel inhibits the conductance of electrical signals, a fact that might be relevant, for example, in the control of seizures.

The G protein itself is activated by another protein, a receptor, which gets its cue to carry out its task from chemical messengers known as neurotransmitters. But neurotransmitters are general messengers they can inhibit as well as excite, and the receptors can respond to either message. How, the scientists wanted to know, is the G protein targeted so quickly and precisely to activate the channel?

Reuveny and his team found that the receptor and G protein are physically bound together in a complex, allowing the process to be finely tuned. When the receptor receives a chemical message from the neurotransmitter, it is already hooked up to the correct G protein
'"/>

Contact: Jennifer Manning
jennifer@acwis.org
212-895-7952
American Committee for the Weizmann Institute of Science
24-Jan-2007


Page: 1 2

Related biology news :

1. Complex ART procedures more likely to lead to umbilical cord abnormality
2. Complexity constrains evolution of human brain genes
3. New method to analyse the Major Histocompatibility Complex (MHC) of the human genome
4. Complex gene interactions account for autism risk
5. Semiconductor membrane mimics biological behavior of ion channels
6. Brain networks strengthened by closing ion channels
7. One protein, two channels: Scientists explain mechanism in aquaporins
8. Gatekeeping: Penn researchers find new way to open ion channels in cell membranes
9. Microchannels, electricity aid drug discovery, early diagnosis
10. New research provides evidence that Rh proteins act as CO2 gas channels

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Complex channels

(Date:8/12/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is proud to announce that iMedNet ... technology platform, has led the way to significant and ... 2015.   Q2 2015 and Q1 2015 were, respectively, ... value sold in the company,s 15 year history.  In ...
(Date:8/10/2015)... TELTOW, Germany , August 10, 2015 ... a world leader in Eye Tracking Technology for more ... OEM Eye Tracking Platform for integration into all consumer ... reference designs for seamless integration of eye tracking into ... HMDs and augmented reality smart glasses. Omnivision,s leading sensor ...
(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
(Date:8/31/2015)... CAESAREA, Israel , Aug. 31, 2015 /PRNewswire/ ... the Dario™ Diabetes Management Solution, today announced it ... $2.5 million. Funds will be used to support ... of the Dario, a mobile, cloud-based, diabetes management ... a stylish, ,all-in-one, pocket-sized, blood glucose monitoring device, ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Food ... food and beverage processors, equipment manufacturers and leaders in the field of academia. ... weighing and formulation for manufacturers of bakery and snacks; beverages; dairy; meat, poultry ...
(Date:8/30/2015)... , August 31, 2015 ... einer Frau   für chirurgische   Behandlung     ... 7-90   werden für eine   verheerende   ... Frauen behandeln und die Anzahl ausgebildeter Chirurgen in Kenia ... Astellas gab heute bekannt, dass  Action on Fistula  seit ...
(Date:8/28/2015)... IRVINE, CA (PRWEB) , ... August 28, 2015 ... ... leader in Personalized Medicine, presented two studies at the International Spine Intervention ... on July 28th, 2015 through to August 1st, 2015. With a focus on ...
Breaking Biology Technology:LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 2LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 3LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 4METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4
Cached News: