HOME >> BIOLOGY >> NEWS
Complexity constrains evolution of human brain genes

Despite the explosive growth in size and complexity of the human brain, the pace of evolutionary change among the thousands of genes expressed in brain tissue has actually slowed since the split, millions of years ago, between human and chimpanzee, an international research team reports in the December 26, 2006, issue of the journal, PLOS Biology.

The rapid advance of the human brain, the authors maintain, has not been driven by evolution of protein sequences. The higher complexity of the biochemical network in the brain, they suspect, with multiple gene-gene interactions, places strong constraints on the ability of most brain-related genes to change.

"We found that genes expressed in the human brain have in fact slowed down in their evolution, contrary to some earlier reports," says study author Chung-I Wu, professor of ecology and evolution at the University of Chicago. "The more complex the brain, it seems, the more difficult it becomes for brain genes to change. Calibrated against the genomic average, brain-expressed genes in humans appear to have evolved more slowly than in chimpanzee or old-world monkey."

Humans have an exceptionally big brain relative to their body size. Although humans weigh about 20 percent more than chimpanzees, our closest relative, the human brain weighs 250 percent more. How such a massive morphological change occurred over a relatively short evolutionary time has long puzzled biologists.

Previous reports have argued that the genes that regulate brain development and function evolved much more rapidly in humans than in nonhuman primates and other mammals because of natural selection processes unique to the human lineage.

The comparative pace of organ-specific evolution, however, turns out to be difficult to measure. To assess the speed with which both humans and chimpanzees accumulated many small differences in gene sequences accurately, Wu and colleagues in Taiwan and Japan decided t
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
25-Dec-2006


Page: 1 2 3

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. New textbook illuminates the close links between evolutionary and molecular biology
3. Coelacanth fossil sheds light on fin-to-limb evolution
4. Genomics study provides insight into the evolution of unique human traits
5. New proteomics research promises to revolutionize biomedical discovery
6. Species detectives track unseen evolution
7. Study identifies energy efficiency as reason for evolution of upright walking
8. Clues to future evolution of HIV come from African green monkeys
9. Tumor painting revolutionizes fight against cancer
10. Revolutionary global environment fund announces $50M expansion
11. A first-principles model of early evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... ... , ... Pebble Labs USA Inc. , a biotechnology company developing solutions ... mission of improving global food security, announced today that they have been selected as ... and Ag-Tech ' virtual event, a global initiative to drive innovation in feeding future ...
(Date:4/26/2020)... ... April 23, 2020 , ... ... computer miniaturization, backed by FII Tech Growth managed by Fondo Italiano d’Investimento SGR, ... biomedical market, for the development of Respira, a new non-invasive pulmonary ventilator created ...
(Date:4/22/2020)... ... April 21, 2020 , ... Captis ... venture capital firm that provides patent development support for early stage startups. The ... illnesses such as ovarian cancer and precancerous pancreatic lesions with simple, accurate and ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages ... providing little or no information on the drug’s mechanism of action (MOA). Gene ... compounds by measuring the activity of molecular pathways. This information can complement phenotypic ...
(Date:5/5/2020)... TAMPA, Fla. (PRWEB) , ... May 05, 2020 ... ... technology and solutions company, announced today the launch of its iGlucose® ... The new iGlucose solution utilizes LTE Cat-M1 technology, the industry’s newest and broadest ...
(Date:4/22/2020)... (PRWEB) , ... April 20, 2020 , ... ... offices in Cambridge, MA, announced today that Omixon’s founder and chairman Dr. Attila ... of Omixon’s flagship product Holotype HLA since 2014 before stepping into the CEO ...
(Date:4/7/2020)... , ... April 06, 2020 , ... Gateway Genomics ... children, reached 200,000 SneakPeek Early Gender DNA Tests sold in March, just ... was launched as an ecommerce product, where a mom could order her kit online, ...
Breaking Biology Technology:
Cached News: