HOME >> BIOLOGY >> NEWS
Complexity constrains evolution of human brain genes

o sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available genomic sequences from human, chimpanzee, and mice.

What they found was that the "more advanced" species had faster overall rates of evolution. So, on average, the genes from humans and chimpanzees changed faster than genes from monkeys, which changed faster than those from mice.

They explained the trend as a correlate of smaller population size in the more advanced species. Species with smaller population size can more easily escape the harsh scrutiny of natural selection.

When they compared the pace of evolution among genes expressed in the brain, however, the order was reversed. When calibrated against the genomic average, brain genes in humans evolved more slowly than in other primates, which were slower than mice.

"We would expect positive selection to work most effectively on tissue-specific genes, where there would be fewer conflicting requirements," says Wu. "For example, genes expressed only in male reproductive tissues have evolved very rapidly."

Brains, however, "are intriguing in this respect," Wu says. Genes that are expressed only in the brain evolved more slowly than those that are expressed in the brain as well as other tissues, and those genes evolved more slowly than genes expressed throughout the rest of the organism.

The authors attribute the slowdown to mounting complexity of interactions within the brain. "We know that proteins with more interacting partners evolve more slowly," Wu said. "Mutations that disrupt existing interactions aren't tolerated."

Although the gene sequences from human and chimpanzee remain very similar, previous studies in tissues other than the brain have shown that gene expression varies widely. Other studies have found that, within the brain, the abundance of expressed genes per neuron appears to be greater in humans.

"On t
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
25-Dec-2006


Page: 1 2 3

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. New textbook illuminates the close links between evolutionary and molecular biology
3. Coelacanth fossil sheds light on fin-to-limb evolution
4. Genomics study provides insight into the evolution of unique human traits
5. New proteomics research promises to revolutionize biomedical discovery
6. Species detectives track unseen evolution
7. Study identifies energy efficiency as reason for evolution of upright walking
8. Clues to future evolution of HIV come from African green monkeys
9. Tumor painting revolutionizes fight against cancer
10. Revolutionary global environment fund announces $50M expansion
11. A first-principles model of early evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... ... 09, 2017 , ... At its national board meeting in North Carolina, ... University’s Departments of Physics and Astronomy, has been selected for membership in ARCS ... for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the ... and accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their ...
(Date:10/5/2017)... ... 05, 2017 , ... LabRoots , the leading provider of educational and ... giving back to cancer research with a month-long promotion supporting the advancement of breast ... shoppers can use promo code PinkRibbon to get 10 percent off their purchase of ...
Breaking Biology Technology:
Cached News: