HOME >> BIOLOGY >> NEWS
Complexity constrains evolution of human brain genes

o sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available genomic sequences from human, chimpanzee, and mice.

What they found was that the "more advanced" species had faster overall rates of evolution. So, on average, the genes from humans and chimpanzees changed faster than genes from monkeys, which changed faster than those from mice.

They explained the trend as a correlate of smaller population size in the more advanced species. Species with smaller population size can more easily escape the harsh scrutiny of natural selection.

When they compared the pace of evolution among genes expressed in the brain, however, the order was reversed. When calibrated against the genomic average, brain genes in humans evolved more slowly than in other primates, which were slower than mice.

"We would expect positive selection to work most effectively on tissue-specific genes, where there would be fewer conflicting requirements," says Wu. "For example, genes expressed only in male reproductive tissues have evolved very rapidly."

Brains, however, "are intriguing in this respect," Wu says. Genes that are expressed only in the brain evolved more slowly than those that are expressed in the brain as well as other tissues, and those genes evolved more slowly than genes expressed throughout the rest of the organism.

The authors attribute the slowdown to mounting complexity of interactions within the brain. "We know that proteins with more interacting partners evolve more slowly," Wu said. "Mutations that disrupt existing interactions aren't tolerated."

Although the gene sequences from human and chimpanzee remain very similar, previous studies in tissues other than the brain have shown that gene expression varies widely. Other studies have found that, within the brain, the abundance of expressed genes per neuron appears to be greater in humans.

"On t
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
25-Dec-2006


Page: 1 2 3

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. New textbook illuminates the close links between evolutionary and molecular biology
3. Coelacanth fossil sheds light on fin-to-limb evolution
4. Genomics study provides insight into the evolution of unique human traits
5. New proteomics research promises to revolutionize biomedical discovery
6. Species detectives track unseen evolution
7. Study identifies energy efficiency as reason for evolution of upright walking
8. Clues to future evolution of HIV come from African green monkeys
9. Tumor painting revolutionizes fight against cancer
10. Revolutionary global environment fund announces $50M expansion
11. A first-principles model of early evolution

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Complexity constrains evolution human brain genes

(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Global Wearable Technologies Market and ... Overview, Trends and Forecast 2014-2020" report to ... are smart devices that can be worn on ...
(Date:1/22/2015)... CHARLOTTE, N.C. , Jan. 22, 2015 Infinisource has ... introduction of the G2 model. The G2 sets a higher ... company,s iSolved human capital management solution. With plug-and-play installation, touch ... G2 time clock provides a robust time collection solution for ...
(Date:12/22/2014)... Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces it has ... for the 2015 International CES debut of the Wocket™ ... will be at the NXT-ID booth January 6th and 7 ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2Infinisource's NXG series sets new time clock standard 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
(Date:1/23/2015)... Portal Solutions , a technology consulting firm that ... 365 and SharePoint platforms , today announces its inclusion in ... of the region’s fastest-growing mid-sized companies based on a combined ... be recognized a second year in a row by SmartCEO ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 ... technologies such as the Bioruptor® and complete solutions ... system for chromatin immunoprecipitation, alleviating the need for ... and controls needed for ChIP of histones or ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
Cached News: