HOME >> BIOLOGY >> NEWS
Components in grapes inhibit enzyme key to proliferation of cancer cells

CHAMPAIGN, Ill. -- Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells, say scientists at the University of Illinois at Urbana-Champaign.

The work -- done using advanced molecular tools with grape-cell cultures and the target enzyme for new anti-cancer strategies -- helps to identify which flavonoids in grapes and red wine are most responsible for anti-cancer qualities, said Mary Ann Lila, a professor in the department of natural resources and environmental sciences.

Flavonoids are a group of organic compounds that include numerous water-soluble plant pigments responsible for colors. They are more abundant in red than in white grapes.

The Journal of Agricultural and Food Chemistry has posted the Illinois study online ahead of regular publication. The study details a dozen newly discovered constituents in grape-cell culture extracts and how some of them work synergistically against an enzyme known as human DNA topoisomerase II. The enzyme is necessary for the spread of cancer and commonly used in cancer research to screen plant chemicals.

"The findings add to the argument for eating whole foods," said Elvira Gonzalez de Mejia, a professor in the department of food science and human nutrition. "It's very clear that the synergy is critical. When a cell becomes malignant that enzyme is expressed 300 times more than in a normal cell. If we can find a compound or mixture of compounds that can reduce the activity of that enzyme, the cancerous cells will die."

The synergistic activity involves specific phytochemicals from the proanthocyanidin and anthocyanin classes of the varied flavonoid family. They worked more effectively against the enzyme than do the previously identified flavonoids quercetin and resveratrol. Alone, the individual compenents had less effect on the enzyme.

"We definitely had very potent activity
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
29-Mar-2005


Page: 1 2 3

Related biology news :

1. Vineyard weeds found to host Pierces disease of grapes
2. COX-2 inhibitors delay pancreatic cancer precursors in mice
3. New use for a cell toxin found to inhibit survival proteins in cancer cells
4. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
5. Alzheimers drug based on Purdue -- designed inhibitor begins clinical trials
6. Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
7. Study reveals how some molecules inhibit growth of lung cancer cells
8. Green tea and COX-2 inhibitors combine to slow growth of prostate cancer
9. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
10. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
11. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2019)... , ... October 04, 2019 , ... ... will be held November 10 at the Grand Elysée Hamburg Rothenbaumchaussee in Hamburg. ... Europe again this November,” said Miao Guo, Vice President of Operations and spokesperson ...
(Date:10/3/2019)... ... October 01, 2019 , ... The ... of chemicals, reagents, and medias and to be a more environmentally sustainable evolution ... culmination of years of experience and feedback from the original version we launched ...
(Date:10/3/2019)... ... 02, 2019 , ... Connecticut Innovations (CI), Connecticut’s strategic venture ... innovative, growing companies, today announced that it has closed on a $750,000 investment ... the 2018 VentureClash competition. , The outlay is part of ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... ... October 02, 2019 , ... Rapid Novor, Inc., ... announce that it has moved into a new, 5000 sqft, purpose-built, state-of-the-art facility. ... facility demonstrates the company's continuous commitment to quality research and service offerings. ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer ... focused on the development of therapies to treat central nervous system (CNS) ...
(Date:9/17/2019)... ... 2019 , ... Catalent, a global leader in clinical supply ... Pacific (APAC) will present at the upcoming 3rd Annual Accelerating Clinical Trials in ... Thursday, Sept. 26, at 10:10 a.m., Ms. Delaney will present “Singapore: APAC’s Clinical ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... ... Nationwide via CNBC on Saturday, September 21st @11:00am ET. Check local listings for ... Pte. Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to ...
Breaking Biology Technology:
Cached News: