HOME >> BIOLOGY >> NEWS
Components in grapes inhibit enzyme key to proliferation of cancer cells

CHAMPAIGN, Ill. -- Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells, say scientists at the University of Illinois at Urbana-Champaign.

The work -- done using advanced molecular tools with grape-cell cultures and the target enzyme for new anti-cancer strategies -- helps to identify which flavonoids in grapes and red wine are most responsible for anti-cancer qualities, said Mary Ann Lila, a professor in the department of natural resources and environmental sciences.

Flavonoids are a group of organic compounds that include numerous water-soluble plant pigments responsible for colors. They are more abundant in red than in white grapes.

The Journal of Agricultural and Food Chemistry has posted the Illinois study online ahead of regular publication. The study details a dozen newly discovered constituents in grape-cell culture extracts and how some of them work synergistically against an enzyme known as human DNA topoisomerase II. The enzyme is necessary for the spread of cancer and commonly used in cancer research to screen plant chemicals.

"The findings add to the argument for eating whole foods," said Elvira Gonzalez de Mejia, a professor in the department of food science and human nutrition. "It's very clear that the synergy is critical. When a cell becomes malignant that enzyme is expressed 300 times more than in a normal cell. If we can find a compound or mixture of compounds that can reduce the activity of that enzyme, the cancerous cells will die."

The synergistic activity involves specific phytochemicals from the proanthocyanidin and anthocyanin classes of the varied flavonoid family. They worked more effectively against the enzyme than do the previously identified flavonoids quercetin and resveratrol. Alone, the individual compenents had less effect on the enzyme.

"We definitely had very potent activity
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
29-Mar-2005


Page: 1 2 3

Related biology news :

1. Vineyard weeds found to host Pierces disease of grapes
2. COX-2 inhibitors delay pancreatic cancer precursors in mice
3. New use for a cell toxin found to inhibit survival proteins in cancer cells
4. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
5. Alzheimers drug based on Purdue -- designed inhibitor begins clinical trials
6. Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
7. Study reveals how some molecules inhibit growth of lung cancer cells
8. Green tea and COX-2 inhibitors combine to slow growth of prostate cancer
9. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
10. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
11. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... ... February 06, 2020 , ... Syntactx, ... device and pharmaceutical trials, announced that Ms. Dorothy Abel has joined the ... oversees the development and execution of regulatory plans designed to help clients ...
(Date:2/1/2020)... ... 01, 2020 , ... Liver cancer, called hepatocellular carcinoma (HCC), occurs each year ... disease. HCC is the 5th most common cancer and the 2nd leading cause of ... to incidence of HCC, while China has half of all patients suffering from liver ...
(Date:1/29/2020)... ... January 29, 2020 , ... ... it will start production of a DNA vaccine against the novel coronavirus (2019-nCoV) ... Pharmaceuticals. A grant of up to $9 million from the Coalition for Epidemic ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... The impact of new medicines, ... laboratory and clinical services during the first two decades of the 21st century ... Slone Partners celebrates its 20th anniversary this year, its evolution as ...
(Date:1/22/2020)... FRANKLIN, Wis. (PRWEB) , ... January 21, 2020 ... ... announce the hiring of Darrell Taylor as Southern Midwest Region Industrial and Institutional ... to the SporActiv™ product line. , Darrell brings over 30 years ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... services, today announced the acquisition of Cunesoft, a move that expands the company’s ... objectives of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent ...
(Date:1/7/2020)... ... January 07, 2020 , ... Absolute Antibody Ltd. ... launch of its VivopureX™ recombinant mouse antibodies for in vivo research in mouse ... or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve ...
Breaking Biology Technology:
Cached News: