HOME >> BIOLOGY >> NEWS
Compound from Chinese medicine shows promise in head and neck cancer, U-M study finds

ANN ARBOR, Mich. -- A compound derived from cottonseed oil could help improve the effectiveness of chemotherapy at treating head and neck cancer, researchers at the University of Michigan Comprehensive Cancer Center have found.

The findings, which will be presented Tuesday, April 19, at the American Association for Cancer Research annual meeting, could lead to a treatment that provides an effective option to surgically removing the cancer, helping patients preserve vital organs involved in speech and swallowing.

While new treatments in head and neck cancer have allowed some patients to undergo chemotherapy and radiation therapy instead of surgery, this form of cancer is often resistant to chemotherapy. When the cancer does not respond to these powerful drugs, patients must resort to surgery.

"Patients really benefit long-term by avoiding surgery because the side effects of surgery for head and neck cancer can be particularly difficult for patients it's how you talk, and how you swallow and how you breathe," says Carol Bradford, M.D., professor of otolaryngology at the U-M Medical School and co-director of the Head and Neck Oncology Program at the U-M Comprehensive Cancer Center.

The compound, (-)-gossypol, works to regulate a protein called Bcl-xL that's overexpressed in cancer cells and makes these cells survive when they shouldn't. Shaomeng Wang, Ph.D., co-director of the Molecular Therapeutics Program at the U-M Comprehensive Cancer Center, discovered (-)-gossypol, a compound derived from a component of Chinese medicine. Gossypol comes from cottonseed oil and was once used in China as a male contraceptive. More recently, it's been tested as a cancer treatment. Wang found the negative isomer of gossypol binds at a site to block the active Bcl-xL protein. A prior study conducted by researchers in the U-M Head and Neck Oncology Program showed Bcl-xL protein is often highly expressed in head and neck cancers.

In this study, r
'"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
19-Apr-2005


Page: 1 2 3

Related biology news :

1. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
2. Compound eyes, evolutionary ties
3. Compounds in cranberry juice show promise as alternatives to antibiotics
4. Compound in wine reduces levels of Alzheimers disease-causing peptides
5. Compound reveals new link between signaling protein and cell migration
6. Compound from Chinese medicine shows promise in head and neck cancer
7. Animal study: Compounds in cranberries may have heart-healthy effects
8. Compounds in plastic packaging act as environmental estrogens altering breast genes
9. Compound inhibits one critical pathway in breast cancer growth
10. Compound from rare plant shows promise in treating breast cancer
11. Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... 25, 2017 , ... Leaders of Quorum Review IRB and ... sessions at this week’s Association of Clinical Research Professionals (ACRP) 2017 Meeting & ... research. , "We are excited to present subject matter expertise on topics that impact ...
(Date:4/21/2017)... ... 21, 2017 , ... The University of Connecticut, in partnership ... three startups through the UConn Innovation Fund. The $1.5 million UConn Innovation Fund ... UConn. , The UConn Innovation Fund provides investments of up to $100,000 to ...
(Date:4/20/2017)... Linda, Ca (PRWEB) , ... April 20, 2017 ... ... University Virtual Event , this new webinar will explore challenging patient cases when ... admitted to the hospital, there may be a need for bridging parental anticoagulation ...
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, a learning technology veteran, ... of experience in the learning technologies industry, Mastin joins NetDimensions from the New York ... plc (LTG). At LEO, Mastin served as SVP of the North America offices and ...
Breaking Biology Technology:
Cached News: