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Compound from rare plant shows promise in treating breast cancer

CHARLOTTESVILLE, Va., Feb. 1, 2005 -- They started with a bare room and an idea. Now, after five years of painstaking, sophisticated tests, scientists at the University of Virginia Health System have discovered that a compound, derived from a rare South American plant, stops the growth of human breast cancer cells in laboratory cultures.

U. Va. Health System scientists Deborah Lannigan and Jeffrey Smith hope that, after further testing, their discovery could translate into a successful drug for the treatment of breast cancer. The disease is the second leading cancer killer of women in the U.S., according to the American Cancer Society, with an estimated 40,410 deaths.

The compound, called SL0101, comes from the plant Forsteronia refracta, a nondescript member of the dogbane family found in the Amazonian rain forest. The compound works like a key in a molecular lock. It inhibits the action of a cancer-linked protein called RSK, which the researchers discovered is important for controlling the growth of breast cancer cells. Interestingly, SL0101 does not alter the growth of normal breast cells. The discovery is detailed in the Feb. 1, 2005 issue of the journal Cancer Research and can be found online at: www.cancerres.aacrjournals.org.

"By preventing RSK from working, we completely stopped the growth of breast cancer cells but did not affect the growth of normal breast cells," said Lannigan, an Assistant Professor of Microbiology at the U. Va. Cancer Center. She compares this discovery to the development of the drug Gleevec for the treatment of chronic myeloid leukemia. Like Gleevec, SL0101 is a signal transduction inhibitor that interferes with the pathways that signal the growth of tumors. "Gleevec is an exciting discovery and we're hoping to have similar success with SL0101," Lannigan said.

For now, Lannigan and Smith have begun testing the compound in anima
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Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
1-Feb-2005


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