HOME >> BIOLOGY >> NEWS
Compound inhibits one critical pathway in breast cancer growth

COLUMBUS, Ohio A compound that suppresses the growth of cancer cells and is relatively non-toxic to normal cells may one day be useful for treating several types of cancer, researchers report in this week's Proceedings of the National Academy of Sciences.

Laboratory experiments in human breast cancer cells suggest that the compound inhibits the constant activation of a protein called Stat3 that is found in several different types of cancer, including cancer of the breast, lung, prostate, head and neck, skin, pancreas and ovaries as well as lymphoma and certain kinds of leukemia.

Stat3 is constantly activated in about 60 percent of breast tumors, said Jiayuh Lin, the study's lead author and an associate professor of pediatrics at Ohio State University.

All cells contain Stat3 protein, but in normal cells, Stat3 activities are only turned on temporarily. Researchers do know, however, that Stat3 is constantly turned on in certain tumor cells.

"The cancer cells we studied seem to depend on Stat3 for survival," said Lin. "When we blocked the chain of events that activate Stat3, the cancer cells died."

Lin is also a member of Ohio State's Comprehensive Cancer Center and an investigator in the Center for Childhood Cancer at Columbus Children's Research Institute. He co-authored the study with Shaomeng Wang, Hui Song and Renxiao Wang, all with the University of Michigan Comprehensive Cancer Center.

The researchers named the compound STA-21. They tested STA-21 after using a computer program to narrow down a list of potential compounds to a manageable number that they could physically test in the lab.

When the computer screening process ended, the researchers tested the 100 top compounds. They tested these compounds on human breast cancer cells in order to find which one best stopped the constant Stat3 activation. STA-21 appeared to be the best inhibitor of Stat3 activity.

"This compound showed a remarkab
'"/>

Contact: Jiayuh Lin
linj@ccri.net
614-355-2652
Ohio State University
7-Mar-2005


Page: 1 2

Related biology news :

1. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
2. Compound eyes, evolutionary ties
3. Compounds in cranberry juice show promise as alternatives to antibiotics
4. Compound in wine reduces levels of Alzheimers disease-causing peptides
5. Compound reveals new link between signaling protein and cell migration
6. Compound from Chinese medicine shows promise in head and neck cancer
7. Animal study: Compounds in cranberries may have heart-healthy effects
8. Compound from Chinese medicine shows promise in head and neck cancer, U-M study finds
9. Compounds in plastic packaging act as environmental estrogens altering breast genes
10. Compound from rare plant shows promise in treating breast cancer
11. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Compound inhibits one critical pathway breast cancer growth

(Date:10/16/2014)... efficiently, they are anything but sustainable: environmental damage ... is becoming increasingly evident. Despite their disadvantages, however, ... regarded as the sole possibility of achieving higher ... Bernhard Schmid, an ecology professor at the University ... agriculture and forestry. After all, a new study ...
(Date:10/15/2014)... the pandemic risk from strains of influenza virus increases ... ourselves to become complacent that the most substantial threats ... , Influenza pandemics arise when a new virus strain ... immunity – spreads in the human population. There have ... the worst of which – the 1918 Spanish Flu ...
(Date:10/15/2014)... Conn. , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market releases ... MarketSite in Times Square on Monday October 13 th . ... CTO David Tunnel and angel investor Mr. Chad ... Pereira , CEO of NXT-ID thanked his investors and employees "for ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
(Date:10/19/2014)... October 19, 2014 The report "Chocolate, ... Share, Trade, Prices, Geography Trend and Forecast (2011 - ... category, and geography and studies the major market drivers, ... America, Europe, and Asia. , The global chocolate market ... $98.3 billion in 2016 at an estimated CAGR of ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
(Date:10/18/2014)... 2014 The report "1,6-Hexanediol Market ... Forecasts to 2019", analyzes the global market on ... understand the industry details such as the key ... geographic regions. , Browse 81 Market Data Tables ... in-depth TOC on “1,6-Hexanediol Market by Application and ...
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market ... with analysis and forecast of revenue. This market was ... to reach $380.0 million by 2018, at a CAGR ... the TOC of the Asia-Pacific LCoS display market report, ... This also provides a glimpse of the segmentation of ...
Breaking Biology Technology:Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3
Cached News: