HOME >> BIOLOGY >> NEWS
Computer tool helps pinpoint risky gene mutations

Certain cancer risks can be passed down through families, the result of tiny changes in a family's genetic code. But not all genetic changes are deadly. To help medical counselors and physicians identify the mutations that pose the greatest health risks, researchers at four institutions, including Johns Hopkins, have developed and validated a new computer tool.

The system, described in the Feb. 16 issue of Public Library of Science Computational Biology, evaluates 16 "predictive features" to help answer a critical question: Is a particular mutation a harmless variation or a genetic glitch that could set the stage for cancer? In blind biochemical tests involving 36 samples containing genetic mutations whose association with breast and ovarian cancer was unknown, the computer tool demonstrated an accuracy rate exceeding 94 percent in identifying protein functions that are believed to be linked to a higher risk of cancer.

The researchers cautioned that the computer tool by itself cannot yet predict future cancer cases. But they believe it can be a fast and useful supplement to traditional biochemical tests, which are far more time-consuming, costly and labor-intensive, and do not always yield conclusive results.

"When people are diagnosed with certain types of cancer, other family members sometimes get genetic testing to find out if they, too, are predisposed to this disease," said Rachel Karchin, an assistant professor of biomedical engineering at Johns Hopkins and lead author of the journal article. "But sometimes, the standard tests find small genetic variations that may be harmful or benign. Our computational test may help pinpoint which one it is. We hope the system will eventually give counselors and doctors an important new tool to help them advise patients about whether they need to take preventive steps to keep cancer from developing."

Karchin, who earned a doctorate in computer science from the University of Californ
'"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
15-Feb-2007


Page: 1 2 3

Related biology news :

1. Computer graphics spills from milk to medicine
2. Computer science professor awarded $400,000 from National Science Foundation
3. Computer model maps efficient inoculation of hospital staff in pandemic outbreak
4. Executable biology -- Computer science sheds light on animal development
5. First impressions: Computer model behaves like humans on visual categorization task
6. Computer-designed molecule to clean up fluorocarbons?
7. Computer scientists join in search for ivory-billed woodpecker
8. Computer program bridges gap between scientists, water policy makers
9. Computer card game detects cognitive changes
10. Computers to save unique type of American red squirrel
11. Computer simulation hints at new HIV drug target

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... Texas (PRWEB) , ... December 04, 2018 , ... ... supplier, has announced the much-anticipated launch of their 100-liter (26 gallon) SAFEthread Drum. ... SAFEthread Drum in 2017, which brought a much-needed modern redesign to the ...
(Date:11/29/2018)... Calif. (PRWEB) , ... November 29, 2018 , ... ... Technologies, is excited to collaborate with the new NSF Engineering Research Center for ... and clinical collaborators brought together to develop transformative tools and technologies for the ...
(Date:11/27/2018)... (PRWEB) , ... November 26, 2018 , ... ... Dr. Brandon Wuerth, MD, Founder of the website IBDwatch and Gastroenterology Fellow at ... leading scientists and doctors from around the world, Dr. Wuerth will bring to ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... November 12, 2018 , ... Dr. Dan ... and Sandy Springs, now welcomes new patients for MTM® Clear Aligners. Offering a ... to traditional braces in the Sandy Springs and Alpharetta areas. Constantly on the ...
(Date:11/9/2018)... ... 2018 , ... uBiome, the leader in microbial genomics, announces ... of Andes Biotechnologies, to its Scientific Advisory Board. Joining the board of leading ... on the genetic studies of hepatitis viruses. The appointment will help uBiome continue ...
(Date:11/6/2018)... ... November 06, 2018 , ... Crucial ... trial data collection and management. TrialKit ™, an eClinical platform, has incorporated ... can quickly and easily sign in to the app via facial recognition or ...
(Date:11/3/2018)... Va. (PRWEB) , ... November 01, 2018 , ... ... first-ever Metrics Champion Consortium Summit. Dr. Jean Mulinde, Senior Advisor, Division of Clinical ... manage risk, monitor safety and ensure data reliability. , What should clinical research ...
Breaking Biology Technology:
Cached News: