HOME >> BIOLOGY >> NEWS
Computer tool helps pinpoint risky gene mutations

Certain cancer risks can be passed down through families, the result of tiny changes in a family's genetic code. But not all genetic changes are deadly. To help medical counselors and physicians identify the mutations that pose the greatest health risks, researchers at four institutions, including Johns Hopkins, have developed and validated a new computer tool.

The system, described in the Feb. 16 issue of Public Library of Science Computational Biology, evaluates 16 "predictive features" to help answer a critical question: Is a particular mutation a harmless variation or a genetic glitch that could set the stage for cancer? In blind biochemical tests involving 36 samples containing genetic mutations whose association with breast and ovarian cancer was unknown, the computer tool demonstrated an accuracy rate exceeding 94 percent in identifying protein functions that are believed to be linked to a higher risk of cancer.

The researchers cautioned that the computer tool by itself cannot yet predict future cancer cases. But they believe it can be a fast and useful supplement to traditional biochemical tests, which are far more time-consuming, costly and labor-intensive, and do not always yield conclusive results.

"When people are diagnosed with certain types of cancer, other family members sometimes get genetic testing to find out if they, too, are predisposed to this disease," said Rachel Karchin, an assistant professor of biomedical engineering at Johns Hopkins and lead author of the journal article. "But sometimes, the standard tests find small genetic variations that may be harmful or benign. Our computational test may help pinpoint which one it is. We hope the system will eventually give counselors and doctors an important new tool to help them advise patients about whether they need to take preventive steps to keep cancer from developing."

Karchin, who earned a doctorate in computer science from the University of Californ
'"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
15-Feb-2007


Page: 1 2 3

Related biology news :

1. Computer graphics spills from milk to medicine
2. Computer science professor awarded $400,000 from National Science Foundation
3. Computer model maps efficient inoculation of hospital staff in pandemic outbreak
4. Executable biology -- Computer science sheds light on animal development
5. First impressions: Computer model behaves like humans on visual categorization task
6. Computer-designed molecule to clean up fluorocarbons?
7. Computer scientists join in search for ivory-billed woodpecker
8. Computer program bridges gap between scientists, water policy makers
9. Computer card game detects cognitive changes
10. Computers to save unique type of American red squirrel
11. Computer simulation hints at new HIV drug target

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2019)... ... April 30, 2019 , ... Philadelphia intellectual ... to announce that Gunes Bender, Ph.D., a registered patent agent, has joined the ... his new role, Bender provides technical support and scientific expertise in the pharmaceutical ...
(Date:4/27/2019)... ANGELES (PRWEB) , ... April ... ... (SDi) flagship market research study " 2019 Global Assessment Report: The Laboratory ... different product categories is presented in 10 sections that include chromatography, life ...
(Date:4/25/2019)... ... , ... In recent years the neurocognitive effects of treatments ... cases the magnitude of these deficits and the long-term impact on cognitive maturation ... may impact developmental trajectories, and patients are often so unwell at the time ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... 2019 , ... Frank is an albino, deaf Great Dane. His owners rescued him when he ... health issues. Despite his hearing impairment, he was always an active and playful pup. Frank ... day, every day. As the two grew, playtime became rougher and Frank ended up injuring ...
(Date:4/16/2019)... ... April 16, 2019 , ... Fulcrum Biometrics , a ... Bank South Pacific (BSP), the largest regionally owned bank in the South Pacific, ... contract to deliver a fingerprint-based Know Your Customer (KYC) banking solution that is ...
(Date:4/10/2019)... ... , ... After more than three months of renovation, Lajollacooks4u is set to ... appliances and modern lighting and fixtures, and will provide additional workspace for the many ... growth in the demand for our team-building events and cooking classes over the last ...
(Date:4/8/2019)... SOUTH JORDAN, Utah and BOSTON (PRWEB) , ... ... ... leader in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the ... provides integration to an unprecedented range of business and contact-orientated applications while ...
Breaking Biology Technology:
Cached News: