Consequences of exposure to an energy rich diet during development

The World Health Organisation recognises the world-wide epidemic increase of obesity-related cardiovascular and metabolic disease as one of the most important health issues of the new millennium. Although this obesity is in part due to the fact that many of us eat a diet high in saturated fat and sugars and do little exercise, there is emerging evidence that the diet that our mothers consume while we are in the womb and also when breast feeding may lead to health risks associated with obesity.

For many years it has been appreciated that fetal undernutrition associated with low birthweight may "programme" the fetus to develop heart disease in adulthood and this phenomenon has been termed "fetal or developmental programming". Converging lines of evidence now suggest that maternal overnutrition and obesity in pregnancy may be just as harmful to the developing baby as undernutrition. In our review entitled "Experimental models of developmental programming: consequences of exposure to an energy rich diet during development" we describe a range of studies in both humans and experimental models that examine the consequences of a maternal diet that is high in fat or caloric intake. Overall, it appears that an individual's appetite and cardiovascular risk may be "programmed" by excess maternal energy intake so predisposing an individual to diabetes or raised blood pressure later in life.

Also in this issue, our laboratory presents results from a recent study entitled "Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy". In this paper we show that rats eating a high fat diet when pregnant give birth to offspring that develop abnormalities in their large arteries similar to those associated with heart disease in man. Adult offspring also showed abnormal activity of vital proteins in the kidney.

We do not know what the ideal diet would be during pregnancy, however, it is clear from our research a

Contact: Lucy Mansfield
Blackwell Publishing Ltd.

Page: 1 2

Related biology news :

1. Reading ability protects brain from lead exposure
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Early environmental exposure may accelerate age-related neurodegeneration
4. Lung and bladder cancer deaths continue decades after arsenic exposure
5. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
6. Study confirms the risk of exposure to secondhand tobacco smoke outdoors
7. Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
8. Early exposure to indoor fungus molecules may protect infants against future allergies
9. New methods and tools needed to measure exposure to airborne nanomaterials
10. Genomic test could help detect radioactivity exposure from terrorist attacks
11. Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns

Post Your Comments:

(Date:5/21/2019)... ... ... Dr. David Greene , Founder and CEO of R3 Stem Cell, ... the Rescue, was produced by Award Winning filmmaker Dr. Elliott Haimoff. , In the ... safety of the procedures along with the potential for helping patients avoid potentially risky ...
(Date:5/21/2019)... , ... May 21, 2019 , ... At their May ... for Tissue Engineered Medical Products (TEMPs) of the American Society for Testing and ... . Gaining this approval was the next step in the company’s plan to ...
(Date:5/15/2019)... ... 15, 2019 , ... The conventional method for characterizing brain ... ultra-thin two-dimensional slices, placed on glass microscope slides and qualitatively evaluated after staining. ... the brain is a highly heterogenous and complex tissue that is challenging to ...
Breaking Biology News(10 mins):
(Date:4/18/2019)... ... 2019 , ... Taking a step closer to a “green” ... Worcester Polytechnic Institute (WPI) has developed a novel process using an unusual solvent ... other biofuels more economically. , Isobutanol, like ethanol, is an alcohol, but its ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... have locked into multiple agreements to help companies advance their innovations to ... industry, ranging from synthetic biology companies that are gene editing therapeutic cells ...
(Date:4/8/2019)... JORDAN, Utah and BOSTON (PRWEB) , ... April ... ... in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the launch ... provides integration to an unprecedented range of business and contact-orientated applications while using ...
(Date:3/29/2019)... ... March 28, 2019 , ... ... milestones, CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ ... which is on top of the $1.7 million already awarded by CARB-X. The ...
Breaking Biology Technology:
Cached News: