HOME >> BIOLOGY >> NEWS
Consortium seeks comment on gene expression roadmap

The External RNA Controls Consortium (ERCC) has issued for comment a draft plan for the selection and qualification of candidate RNA sequences, to be used as controls for assessing the performance of gene expression experiments. The ERCC is an ad hoc group of about 50 companies, universities and federal laboratories joined to develop materials and tools that will be used to establish the performance of DNA microarrays and other quantitative experiments that measure gene expression. The National Institute of Standards and Technology (NIST) is a founding member and host of the consortium.

Gene expression--how and under what conditions specific genes produce which proteins, and why--is one of the most important frontiers in bioscience today, promising a better understanding of fundamental life processes and the discovery of important biomarkers for early disease diagnosis. The field was advanced enormously by the development of powerful technologies such as quantitative, real-time reverse transcriptase polymerase chain reaction (QRT-PCR) and the DNA microarray. Both techniques for analyzing gene expression, however, are complex, involve multiple steps, various detection technologies and many potential sources of error. At present, it is difficult to establish the quality of any particular experiment.

The ERCC proposes to develop consistent, well-characterized RNA samples that can be added into gene expression assays as a check on the performance of the measurement system. These proposed "external RNA controls"--approximately 100 are envisioned--would be chosen to deliver comparable results across the range of available microarray and QRT-PCR systems.

Because selecting a set of RNA controls that perform consistently is essential to the success of the project, the ERCC is planning extensive experimental qualification of the set. They are publishing for public comment a draft specification of its proposed methods for testing and selecting the final se
'"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
30-Aug-2005


Page: 1 2

Related biology news :

1. Genome Canada, Gnome Qubec and Universit de Montral launch P3G Consortium and CARTaGENE Project
2. International Genomics Consortium, TGen to lead Biospecimen Core for Cancer Atlas pilot project
3. Consortium for Functional Glycomics awarded $40.7 million glue grant
4. ORNL technologies win maximum Federal Laboratory Consortium awards
5. Consortium to create comprehensive tools for uncovering the functions of human, mouse genes
6. Geisinger scientist seeks cure for Lou Gehrigs disease, creating device to find treatment
7. New research seeks to enhance alternative fuel integration in public vehicle fleets
8. Plant biologist seeks molecular differences between rice and its mimic
9. Spin-out company seeks medicines from South American rain forests
10. Wildlife conservation and energy devt study seeks balance in Rockies
11. Stem cell study for patients with heart attack damage seeks to regenerate heart muscle

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)...  VMS BioMarketing, a leading provider of patient support solutions, ... Educator (CNE) network, which will launch this week. The VMS ... care professionals to enhance the patient care experience by delivering ... health care professionals to help women who have been diagnosed ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology:
Cached News: