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Convergent evolution of molecules in electric fish

Having a set of extra genes gave fish on separate continents the ability to evolve electric organs, report researchers from The University of Texas at Austin.

Dr. Harold Zakon and colleagues, in a paper recently published in Proceedings of the National Academy of Sciences, show that African and South American groups of fish independently evolved electric organs by modifying sodium channel proteins typically used in muscle contraction.

Mutations in sodium channel proteins can cause serious muscular disorders, epilepsy and heart problems in humans and other vertebrates.

But fish have two copies of many of their genes, and Zakon found that the duplicate sodium channel gene could mutate and evolve without harming the fish.

"The spare gene gave [the electric fish] a little bit of evolutionary leeway," says Zakon, professor of neurobiology. "This is really one of the first cases that the ancestral gene duplication in fish has actually been linked to a gene that has been freed up and evolving in accordance with a 'new lifestyle.'"

Zakon and colleagues looked at two sodium channel genes in the electric organs and muscles in electric and non-electric fish. Electric fish use their electric organs, which are modified muscles, to communicate with each other and sense their environment.

The researchers found that electric fishes expressed one of the sodium channel genes in their electric organs only, while non-electric fish express both genes in their muscles.

"Most fish have both genes in the muscle, but as the new electric organ was evolving, the sodium channel--by being lost from the muscle--became devoted to the electric organ," Zakon says. "So two times, independently, the gene has been 'lost' from the muscle. It's no longer able to turn-on in a cell that for millions of years it turned on in, and now it's turning-on in this new organ."

When the research team looked at the sodium channel protein sequenc
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Contact: Lee Clippard
lclippard@mail.utexas.edu
512-232-0675
University of Texas at Austin
3-Mar-2006


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